Poly(ester amide)s are attracting attention because they potentially have excellent thermal and mechanical properties as well as biodegradability. In this study, we synthesized a series of novel poly(ester amide)s by introducing γ-aminobutyric acid (GABA) regularly into polyesters, and investigated their properties and biodegradabilities. GABA is the monomer unit of biodegradable polyamide 4 (PA4). The new poly(ester amide)s were synthesized from the reaction of ammonium tosylate derivatives of alkylene bis(γ-aminobutylate) and -nitrophenyl esters of dicarboxylic acids. All the obtained polymers showed relatively high melting temperatures (). Their thermal decomposition temperatures were improved in comparison with that of PA4 and higher enough than their . The poly(ester amide)s exhibited higher biodegradability in seawater than the corresponding homopolyesters. Their biodegradabilities in activated sludge were also studied.
Download full-text PDF |
Source |
---|---|
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7279392 | PMC |
http://dx.doi.org/10.3390/ijms21103674 | DOI Listing |
Int J Nanomedicine
January 2025
Advanced Diagnostics and Therapeutics Institute, Health Sector, King Abdulaziz City for Science and Technology (KACST), Riyadh, 11442, Saudi Arabia.
Introduction: Wound treatment is a significant health burden in any healthcare system, which requires proper management to minimize pain and prevent bacterial infections that can complicate the wound healing process.
Rationale: There is a need to develop innovative therapies to accelerate wound healing cost-effectively. Herein, two polymer-based nanofibrous systems were developed using poly-lactic-co-glycolic-acid (PLGA) and polyvinylpyrrolidone (PVP) loaded with a combination of an antibiotic (Fusidic acid, FA) and a local anesthetic (Lidocaine, LDC) via electrospinning technique for an expedited healing process by preventing bacterial infections while reducing the pain sensation.
RSC Adv
January 2025
Packing and Packaging Materials Department, Institute of Chemical Industries Research, National Research Centre 33 El Behooth St., Dokki Giza Egypt +20 2 33371718.
Nanofiltration (NF) separation technology is a low-pressure filtration process, which is highly efficient and environmentally friendly. As a result, it has found wide application in water treatment. This work describes the preparation of flat sheet membranes the phase inversion method using blends of hyperbranched polyester amide (PEA) and polyether sulphone (PES) in definite ratios.
View Article and Find Full Text PDFPolymers (Basel)
December 2024
Department of Civil, Chemical, Environmental and Materials Engineering, University of Bologna, Via Terracini 28, 40131 Bologna, Italy.
PEA 46 is a biobased polymer with promising properties for sustainable packaging applications, which can be obtained via polymerization of a furan 2,5-dicarboxylic acid (2,5-FDCA) derivative and a diol monomer containing internal amide bonds (46 amido diol). In the literature, PEA 46 showed a complex series of thermal transitions during DSC scans. For this reason, in this initial exploratory study PEA 46 was subjected to compression molding and the melting behavior of film samples was investigated with parallel DSC and WAXS analyses.
View Article and Find Full Text PDFSci Rep
January 2025
School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, 102488, China.
The main advantages of microneedles are precise drug delivery through human skin, minimal tissue damage and painlessness. We conducted structural analysis and skin puncture studies of hollow microneedles using ANSYS for three materials: Hafnium Dioxide (HfO), Polyglycolic acid (PGA) and Polylactic acid (PLA). Firstly, we selected three lengths, three tip diameters and three base diameters to conduct a L(3) orthogonal experiment.
View Article and Find Full Text PDFInt J Pharm
January 2025
School of Pharmacy, Queen's University Belfast, Belfast, United Kingdom. Electronic address:
Diabetic retinopathy (DR) and age-related macular degeneration (AMD) are the primary causes of vision impairment and blindness worldwide. The current treatment for these diseases is an intravitreal injection of anti-VEGF agents, which are costly and require frequent injections. Implants can be used to sustain the release of drugs and minimize side effects.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!