Thiazole derivatives attract the attention of scientists both in the field of organic synthesis and bioactivity research due to their high biological activity. In the present study, thiazole ring was obtained by the interaction of 1-(4-(bromoacetyl)phenyl)-5-oxopyrrolidine-3-carboxylic acid with thiocarbamide or benzenecarbothioamide, as well as tioureido acid. A series of substituted 1-(3-(1,3-thiazol-2-yl)phenyl)-5-oxopyrrolidines with pyrrolidinone, thiazole, pyrrole, 1,2,4-triazole, oxadiazole and benzimidazole heterocyclic fragments were synthesized and their antibacterial properties were evaluated against Gram-positive strains of , , and Gram-negative , and . The vast majority of compounds exhibited between twofold and 16-fold increased antibacterial effect against the test-cultures when compared with .

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7288019PMC
http://dx.doi.org/10.3390/molecules25102433DOI Listing

Publication Analysis

Top Keywords

substituted 1-3-13-thiazol-2-ylphenyl-5-oxopyrrolidines
8
synthesis characterization
4
characterization bioassay
4
bioassay novel
4
novel substituted
4
1-3-13-thiazol-2-ylphenyl-5-oxopyrrolidines thiazole
4
thiazole derivatives
4
derivatives attract
4
attract attention
4
attention scientists
4

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!