AI Article Synopsis
Article Abstract
The present study sought to characterize the synthesis pathways producing the essential polyunsaturated fatty acid (PUFA) 20:5n-3 (EPA). For this, the incorporation of C was experimentally monitored into 10 fatty acids (FA) during the growth of the diatom for 24 h preferentially and quickly incorporated C into C PUFAs such as 18:2n-6 and 18:3n-6 as well as 16:0 and 16:1n-7, which were thus highly C-enriched. During the experiment, 20:5n-3 and 16:3n-4 were among the least-enriched fatty acids. The calculation of the enrichment percentage ratio of a fatty acid B over its suspected precursor A allowed us to suggest that the diatom produced 20:5n-3 (EPA) by a combination between the n-3 (via 18:4n-3) and n-6 (via 18:3n-6 and 20:4n-6) synthesis pathways as well as the alternative ω-3 desaturase pathway (via 20:4n-6). In addition, as FA from polar lipids were generally more enriched in C than FA from neutral lipids, particularly for 18:1n-9, 18:2n-6 and 18:3n-6, the existence of acyl-editing mechanisms and connectivity between polar and neutral lipid fatty acid pools were also hypothesized. Because 16:3n-4 and 20:5n-3 presented the same concentration and enrichment dynamics, a structural and metabolic link was proposed between these two PUFAs in .
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7277837 | PMC |
| http://dx.doi.org/10.3390/biom10050797 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Orchestrated desaturation reprogramming from stearoyl-CoA desaturase to fatty acid desaturase 2 in cancer epithelial-mesenchymal transition and metastasis.
Cancer Commun (Lond)
December 2024
Department of Biomedical Engineering, Department of Electrical and Computer Engineering, Photonics Center, Boston University, Boston, Massachusetts, USA.
Background: Adaptative desaturation in fatty acid (FA) is an emerging hallmark of cancer metabolic plasticity. Desaturases such as stearoyl-CoA desaturase (SCD) and fatty acid desaturase 2 (FADS2) have been implicated in multiple cancers, and their dominant and compensatory effects have recently been highlighted. However, how tumors initiate and sustain their self-sufficient FA desaturation to maintain phenotypic transition remains elusive.
View Article and Find Full Text PDFSpraying methyl jasmonate before harvesting can significantly increase the content of icariin in an important leaf medicinal herb, Epimedium sagittatum, by activating the expression of genes involved in flavonoid synthesis pathways.
BMC Plant Biol
December 2024
School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou, 450046, China.
Background: Increased icariin content during the harvesting period is one of the factors limiting the quality improvement of Epimedium sagittatum, and there is currently a lack of scientific and effective biotechnological measures.
Results: In this study, we carried out experiments involving spraying different concentrations (0 µmol·L as control group, 500 µmol·L, 1000 µmol·L and 1500 µmol·L) of methyl jasmonate (MeJA) solution on E. sagittatum leaves.
Peripartum energy metabolism of prolific ewes and their progeny in response to prepartum feeding and litter size.
Animal
November 2024
Département des sciences animales, Université Laval, Pavillon Paul-Comtois, 2425 rue de l'Agriculture, Québec, QC, G1V 0A6, Canada. Electronic address:
In late gestation, the increased energy demand to support the rapid fetal growth can induce an acute negative energy balance associated with a high risk of pregnancy toxemia, especially for prolific ewes (carrying two or more fetuses). The current study was conducted to evaluate the effects of dietary energy during the last 6 weeks prepartum on the energy metabolism dynamic responses and the newborn lamb metabolic profile in prolific ewes. Forty-five crossbred (Dorset × Romanov) ewes were randomly assigned to 1 of 3 dietary energy densities: E: 8.
View Article and Find Full Text PDFMicro-nano bubble ozonation for effective treatment of ibuprofen-laden wastewater and enhanced anaerobic digestion performance.
Water Res
December 2024
School of Environmental Science and Engineering, Sun Yat-sen University, Guangzhou, PR China; Guangdong Provincial Key Laboratory of Environmental Pollution Control and Remediation Technology (Sun Yat-sen University), Guangzhou, PR China. Electronic address:
The pharmaceutical industry plays a crucial role in driving global economic growth but also poses substantial environmental challenges, particularly in the efficient treatment of production wastewater. This study investigates the efficacy of micro-nano bubble (MNB) ozonation for treating high-strength ibuprofen (IBU)-laden wastewater (49.9 ± 2.
View Article and Find Full Text PDFThe effects of industrial processing and home cooking practices on trans-fatty acid profiles of vegetable oils.
Food Chem
December 2024
Department of Food Science, University of Copenhagen, Rolighedsvej 26, 1958 Frederiksberg C, Denmark.
The intake of trans-fatty acids (TFA) is strongly associated with an increased risk of cardiovascular diseases and elevated low-density lipoprotein cholesterol levels in blood. This review explores the critical factors influencing TFA formation during industrial vegetable oil processing and home cooking practices, particularly deep-frying. While hydrogenation, a major source of TFA, has been largely eliminated in developed countries, it remains unregulated in many developing countries, posing significant health risks.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!