The histone deacetylase (HDAC) enzymes have emerged as an important class of molecular targets in cancer therapy, with five inhibitors in clinical use. Recently, it has been shown that a lack of selectivity between the 11 Zn-dependent HDAC isoforms may lead to unwanted side-effects. In this paper, we show that piano stool Ru complexes can act as HDAC inhibitors, and variation in the capping arene leads to differences in HDAC isoform selectivity.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7287671 | PMC |
| http://dx.doi.org/10.3390/molecules25102383 | DOI Listing |
Publication Analysis
Top Keywords
complexes hdac
8
hdac isoform
8
isoform selectivity
8
hdac
5
anticancer ruthenium
4
ruthenium complexes
4
selectivity histone
4
histone deacetylase
4
deacetylase hdac
4
hdac enzymes
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!