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Objectives: The objective was to isolate and characterize the secondary metabolites of , which has not been previously investigated.
Materials And Methods: Conventional chromatographic procedures were carried out for isolation of the compounds. The structures of the compounds were elucidated by extensive 1D and 2D nuclear magnetic resonance spectroscopic analysis in combination with mass spectrometry experiments and comparison with the relevant literature data.
Results: This first phytochemical investigation on all parts of Fenzl led to the isolation and identification of seven known flavonoid glycosides: isoquercetin , rutin , afzelin , astragalin , isorhamnetin 3-O-glucoside , nicotiflorin , and narcissoside .
Conclusion: This is the first report on the isolation of these flavonoid glycosides from and compounds , and from the genus .
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http://dx.doi.org/10.4274/tjps.galenos.2018.53215 | DOI Listing |
J Pharm Biomed Anal
March 2025
School of Pharmacy, Harbin University of Commerce, Harbin 150076, China; Engineering Research Center on Natural Antineoplastic Drugs, Ministry of Education, Harbin University of Commerce, Harbin 150076, China. Electronic address:
As a traditional Chinese medicine for reinforcing kidney, Cuscutae semen can be applied in regulating the level of estrogen. And nine direct-acting substances in vivo with estrogenic effect has been figured out according to our previous research. However, their transformation relationship and the prototype forms of some metabolites are still not clear, impeding the elucidation of the effective substances of Cuscutae semen.
View Article and Find Full Text PDFFree Radic Biol Med
March 2025
Department of Cell Biology & Medical Genetics, School of Basic Medical Sciences, Shenzhen University Medical School, Shenzhen 518060, China. Electronic address:
Astragalin (AST) is a flavonoid glycoside commonly found in edible plants and medicinal herbs with a variety of therapeutic effects. This study aimed to investigate whether AST protects the integrity of the blood-brain barrier (BBB) and inhibits neuroinflammation, thereby alleviating depressive-like behaviors. LPS-stimulated cultured cells and LPS-induced BBB disruption and depressive-like behavior mice models were employed.
View Article and Find Full Text PDFFood Chem
February 2025
Faculty of Chemistry and Technology, University of Split, Ruđera Boškovića 35, 21000 Split, Croatia; Mediterranean Institute for Life Sciences, University of Split, Meštrovićevo šetalište 45, 21000 Split, Croatia.
The first comprehensive investigation of Montpellier maple (Acer monspessulanum L.) honeydew (HD)-to-honeydew honey (HDH) transformation pathway was performed. A leafhopper Acericerus heydenii excreting honeydew on A.
View Article and Find Full Text PDFJ Mater Sci Mater Med
March 2025
Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China.
Local therapy involving injectable hydrogel systems loaded with doxorubicin (DOX) has garnered significant attention in the realm of osteosarcoma (OS) research. Nevertheless, it has been noted that the local delivery of high-dose DOX exerts a pronounced inhibitory impact on osteogenesis, which is detrimental to the restoration of functional capabilities after OS treatment. To address this challenge, we have designed a self-assembled injectable hydrogel system that integrates photodynamic and chemodynamic therapy, aiming to enhance efficacy while mitigating adverse effects on osteogenic differentiation.
View Article and Find Full Text PDFChem Biodivers
March 2025
China Pharmaceutical University, School of Traditional Chinese Pharmacy, Longmian Road 639#, 211198, Nanjing, Jiangsu, CHINA.
Cajanus cajan (L.) Millsp. leaves (CCML), a well-known traditional Chinese medicine, is widely recognized for its protective effects against osteoporosis and osteonecrosis.
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