Synthesis and Aldose Reductase Inhibitory Effect of Some New Hydrazinecarbothioamides and 4-Thiazolidinones Bearing an Imidazo[2,1-]Thiazole Moiety.

Objectives: To synthesize and characterize 2-[[6-(4-bromophenyl)imidazo[2,1-]thiazol-3-yl]acetyl]--alkyl/arylhydrazinecarbothioamide and 3-alkyl/aryl-2-[((6-(4-bromophenyl)imidazo[2,1-]thiazol-3-yl)acetyl)hydrazono]-5-nonsubstituted/methyl-4-thiazolidinone derivatives and evaluate them for their aldose reductase (AR) inhibitory effect.

Materials And Methods: 2-[[6-(4-bromophenyl)imidazo[2,1-]thiazol-3-yl]acetyl]--alkyl/arylhydrazinecarbothioamides () and 3-alkyl/aryl-2-[((6-(4-bromophenyl)imidazo[2,1-]thiazol-3-yl)acetyl)hydrazono]-5-nonsubstituted/methyl-4-thiazolidinones () were synthesized from 2-[6-(4-bromophenyl)imidazo[2,1-]thiazole-3-yl]acetohydrazide (). Their structures were elucidated by elemental analyses and spectroscopic data. The synthesized compounds were tested for their ability to inhibit rat kidney AR.

Results: Among the synthesized compounds, 2-[[6-(4-bromophenyl)imidazo[2,1-]thiazol-3-yl]acetyl]--benzoylhydrazinecarbothioamide () showed the best AR inhibitory activity.

Conclusion: The findings of this study indicate that the different derivatives of the compounds in this study may be considered interesting candidates for future research.