Objectives: The present study aims to assess the antidepressant activity of extracts in mice and phytochemical analysis of the active extract by GC-MS.
Materials And Methods: After oral administration of extracts, tail suspension test (TST), force swim tests (FST), and open field tests (OFT) were performed to assess the antidepressant activity. GC-MS analysis of methanol extract of was performed to ascertain the chemical constituents in the bioactive extract.
Results: The methanol extract of at dose of 100 and 200 mg/kg body weight, p.o. significantly reduced the total duration of immobility in the TST as well as FST (p<0.01). extracts showed no significant changes in locomotor activity in OFT.
Conclusion: The methanol extract of possesses antidepressant-like properties in mice with no significant effect on locomotor activity in OFT.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7228019 | PMC |
| http://dx.doi.org/10.4274/tjps.14622 | DOI Listing |
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