Objectives: The development of oral vaccine formulations has been widely investigated to overcome oral route problems. This research investigated the immune response of ovalbumin-alginate microspheres by uptake compared with a commercial oral vaccine product.
Materials And Methods: Ovalbumin-loaded alginate microspheres were prepared using aerosolization. Ovalbumin antigen uptake was investigated in order to understand the distribution and uptake by Peyer's plaque (PP) after oral administration using fluorescence microscopy. The histopathology of ovalbumin-alginate microspheres in the liver and kidney was also investigated.
Results: The use of alginate microspheres to deliver vaccines could be a promising delivery system for the development of oral vaccines because uptake by PP is an essential step in oral vaccination.
Conclusion: Fluorescence visualization revealed the uptake of ovalbumin-loaded alginate microspheres with and without lyoprotectant maltodextrin by PP was equal to the oral vaccine product and no liver or kidney damage was found.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7227935 | PMC |
| http://dx.doi.org/10.4274/tjps.93585 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Polysaccharide-based drug delivery targeted approach for colon cancer treatment: A comprehensive review.
Int J Biol Macromol
January 2025
Department of Gastroenterology, Shengjing Hospital of China Medical University, Shenyang, Liaoning, China. Electronic address:
Colon cancer is a leading cause of cancer-related morbidity and mortality worldwide, necessitating advancements in therapeutic strategies to improve outcomes. Current treatment modalities, including surgery, chemotherapy, and radiation, are limited by systemic toxicity, low drug utilization rates, and off-target effects. Colon-targeted drug delivery systems (CDDS) offer a promising alternative by leveraging the colon's unique physiology, such as near-neutral pH and extended transit time, to achieve localized and controlled drug release.
View Article and Find Full Text PDFColon-Targeted Ginseng Polysaccharides-Based Microspheres for Improving Ulcerative Colitis via Anti-Inflammation and Gut Microbiota Modulation.
Adv Healthc Mater
January 2025
College of Chinese Medicinal Materials, Jilin Agricultural University, Changchun, 130118, China.
Natural plant-derived polysaccharides exhibit substantial potential for treating ulcerative colitis (UC) owing to their anti-inflammatory and antioxidant properties and favorable safety profiles. However, their practical application faces several challenges, including structural instability in gastric acid, imprecise targeting of inflamed regions, and limited intestinal retention times. To address these limitations, pH-responsive, colon-targeting microspheres (pWGPAC MSs) are developed for delivering phosphorylated wild ginseng polysaccharides (pWGP) to alleviate UC.
View Article and Find Full Text PDFFe, N-CQDs triggered the fabrication of alginate encapsulated g-CN hydrogel for efficient photocatalytic activation of PMS and antibiotic degradation.
Carbohydr Polym
March 2025
School of Environmental and Architecture, University of Shanghai for Science and Technology, Shanghai 200093, China. Electronic address:
Carbon dots (CDs) mediated g-CN (CN) is a promising visible-light-driven semiconductor in catalyzing peroxymonosulfate (PMS) for aqueous contaminants remediation. However, the poor dispersibility of powered catalyst and its challenging recyclability impede their broader application. Herein, we embedded FeN bridge within the g-CN framework and immobilized g-CN gel beads (CA/FNCCN) through a 3D cross-linking process with sodium alginate.
View Article and Find Full Text PDFHybrid Systems of Oleogels and Probiotic-Loaded Alginate Carriers for Potential Application in Cosmetics.
Molecules
December 2024
Department of Engineering and Machinery for Food Industry, University of Agriculture in Krakow, Balicka Street 122, 30-149 Cracow, Poland.
Oleogels (organogels) are systems resembling a solid substance based on the gelation of organic solvents (oil or non-polar liquid) through components of low molecular weight or oil-soluble polymers. Such compounds are organogelators that produce a thermoreversible three-dimensional gel network that captures liquid organic solvents. Oleogels based on natural oils are attracting more attention due to their numerous advantages, such as their unsaturated fatty acid contents, ease of preparation, and safety of use.
View Article and Find Full Text PDFEfficient removal of direct dyes and heavy metal ion by sodium alginate-based hydrogel microspheres: Equilibrium isotherms, kinetics and regeneration performance study.
Int J Biol Macromol
January 2025
Key Laboratory of Marine Chemistry Theory and Technology, Ministry of Education, College of Chemistry and Chemical Engineering, Ocean University of China, Qingdao 266100, China; Open Studio for Marine Corrosion and Protection, Pilot National Laboratory for Marine Science and Technology (Qingdao), Qingdao 266100, China; Key Laboratory of Ocean Observation and Information of Hainan Province, Sanya Oceanographic Institution, Ocean University of China, Sanya 572024, China. Electronic address:
Improving the adsorption capacity of materials for pollutants by means of modification is an important direction in the research of water treatment technology. To improve the applicability of sodium alginate composites in the field of adsorption, magnetic sodium alginate-based hydrogel microsphere adsorbent material FeO@SA/PEI-Fe (FSPF) was synthesized in a single step by using polyethyleneimine grafting modification of sodium alginate by sol-gel method. The material was used for the removal of direct blue GL (DB 200) and direct date red B (DR 13) from simulated wastewater, as well as Cu(II) and Pb(II) from simulated wastewater with heavy metal ions.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!