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Oral glucose-responsive nanoparticles loaded with artemisinin induce pancreatic β-cell regeneration for the treatment of type 2 diabetes.
J Colloid Interface Sci
January 2025
School of Life Science, South China Normal University, Guangzhou 510631 China; Guangzhou Key Laboratory of Spectral Analysis and Functional Probes, College of Biophotonics, South China Normal University, Guangzhou 510631 China; South China Normal University-Panyu Central Hospital Joint Laboratory of Translational Medical Research, Panyu Central Hospital, Guangzhou 511400 China. Electronic address:
Type 2 diabetes (T2D) is a chronic disease characterized by long-term insulin resistance (IR) and pancreatic β-cell dysfunction. Conventional T2D medication ignores pancreatic β-cell damage. In this study, we designed an oral glucose-responsive nanoparticle for pancreatic β-cell regeneration and treatment of T2D.
View Article and Find Full Text PDFPax4-Ghrelin mediates the conversion of pancreatic ε-cells to β-cells after extreme β-cell loss in zebrafish.
Development
March 2023
Institute of Developmental Biology and Regenerative Medicine, Southwest University, Beibei 400715 Chongqing, China.
Pancreatic ε-cells producing ghrelin are one type of endocrine cell found in islets, which have been shown to influence other intra-islet cells, especially in regulating the function of β cells. However, the role of such cells during β-cell regeneration is currently unknown. Here, using a zebrafish nitroreductase (NTR)-mediated β-cell ablation model, we reveal that ghrelin-positive ε-cells in the pancreas act as contributors to neogenic β-cells after extreme β-cell loss.
View Article and Find Full Text PDFDifferentially expressed microRNAs during the differentiation of muscle-derived stem cells into insulin-producing cells, a promoting role of microRNA-708-5p/STK4 axis.
PLoS One
April 2022
Reproductive Medicine Center, Inner Mongolia People's Hospital, Hohhot, Inner Mongolia Autonomous Region, China.
Objective: Stem cell therapy is a promising approach for diabetes via promoting the differentiation of insulin-producing cells (IPCs). This study aimed to screen the differentially expressed miRNAs (DEmiRNAs) during the differentiation of muscle-derived stem cells (MDSCs) into IPCs, and uncover the underlying function and mechanism of a specific DEmiRNA, miR-708-5p.
Methods: MDSCs were successfully isolated from the leg muscle of rats, and were induced for IPCs differentiation through a five-stage protocol.
[Overexpression of PAX4 by gene therapy for type 1 diabetes treatment].
Med Sci (Paris)
May 2020
Laboratoire CarMeN, Inserm U1060, Université Claude Bernard Lyon 1, INRAE U1397, INSA-Lyon, Lyon, France Clinical Research Department, Hospices civils de Lyon, Centre hospitalier Lyon-Sud, Pierre-Bénite, France. - Do-it team, Hospices Civils de Lyon, Bâtiment CENS-ELI, CHU Lyon Sud, Lyon, France.
ISX-9 manipulates endocrine progenitor fate revealing conserved intestinal lineages in mouse and human organoids.
Mol Metab
April 2020
Diabetes Research Group, School of Life Course Sciences, Faculty of Life Science and Medicine, King's College London, London, UK. Electronic address:
Objective: Enteroendocrine cells (EECs) survey the gut luminal environment and coordinate hormonal, immune and neuronal responses to it. They exhibit well-characterised physiological roles ranging from the control of local gut function to whole body metabolism, but little is known regarding the regulatory networks controlling their differentiation, especially in the human gut. The small molecule isoxazole-9 (ISX-9) has been shown to stimulate neuronal and pancreatic beta-cell differentiation, both closely related to EEC differentiation.
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