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Incidence of acute kidney injury and its predictors among neonates admitted at neonatal intensive care unit of, Northwest Ethiopia comprehensive specialized hospitals, 2023.
BMC Pediatr
November 2024
Department of Pediatric and Neonatal Nursing, School of Nursing and Midwifery, Institute of Health Science, Wollega University, Nekemte, Ethiopia.
Article Synopsis
- Acute kidney injury (AKI) is a significant health issue in neonates, particularly in developing regions like Ethiopia, with this study particularly focusing on its incidence and predictors in intensive care settings.
- A retrospective analysis of 634 neonates revealed a 14.9 per 1000 incidence rate of AKI, with various factors such as sepsis, perinatal asphyxia, and specific drug use (like gentamicin) identified as statistically significant predictors.
- This research highlights the need for increased attention to neonatal care in low-resource settings to help reduce morbidity and mortality associated with AKI.
Acute Kidney Injury in Pregnancy: A Prospective Study.
Cureus
April 2024
Medicine, Indira Gandhi Institute of Medical Sciences, Patna, IND.
Article Synopsis
- Acute kidney injury (AKI) during pregnancy is a critical clinical issue linked to high maternal and fetal morbidity, necessitating a study of its causes, symptoms, and outcomes.
- A year-long prospective observational study at Indira Gandhi Institute of Medical Sciences involved 62 patients, primarily aged 18-25, who presented with emergency obstetric complications leading to acute kidney damage.
- The findings revealed that most patients experienced symptoms such as oliguria, fever, and breathlessness, with a significant portion being non-booked and primigravida.
A loss-of-function AGTR1 variant in a critically-ill infant with renal tubular dysgenesis: case presentation and literature review.
BMC Nephrol
April 2024
Laboratory of Genomic Medicine, Sidra Medicine, P.O. Box 26999, Doha, Qatar.
Background: Renal tubular dysgenesis (RTD) is a severe disorder with poor prognosis significantly impacting the proximal tubules of the kidney while maintaining an anatomically normal gross structure. The genetic origin of RTD, involving variants in the ACE, REN, AGT, and AGTR1 genes, affects various enzymes or receptors within the Renin angiotensin system (RAS). This condition manifests prenatally with oligohydramninos and postnatally with persistent anuria, severe refractory hypotension, and defects in skull ossification.
View Article and Find Full Text PDFNeonatal Renal Failure Following Intrauterine Exposure to an Angiotensin-Converting Enzyme Inhibitor.
Cureus
February 2024
Neonatal Intensive Care Unit, Department of Neonatology, Centro Hospitalar Universitário de São João, Porto, PRT.
The renin-angiotensin-aldosterone system (RAAS) plays a crucial role in the normal development of the fetal kidney. Late pregnancy blockage of the RAAS, through in-utero exposure to angiotensin-converting enzyme inhibitors (ACEIs) or angiotensin II receptor blockers, is associated with poor fetal outcomes, including oligohydramnios, renal tubular dysplasia, postnatal anuric renal failure, and hypotension. The present case describes a 39-year-old primigravida that was referred to the emergency department, at 37 weeks, for the evaluation of intrauterine growth restriction and suspected coarctation of the aorta (CoA).
View Article and Find Full Text PDFComplications and prognosis of patients diagnosed with autosomal recessive polycystic kidney disease in neonatal period.
CEN Case Rep
June 2024
Division of Nephrology and Rheumatology, National Center for Child Health and Development, 2-10-1, Okura, Setagaya-ku, Tokyo, 157-8535, Japan.
There are no clinical guidelines for performing nephrectomy in patients with autosomal recessive polycystic kidney disease (ARPKD). Few reports have described the clinical course of ARPKD diagnosed in the neonatal period in detail. Here, we report seven patients diagnosed with ARPKD and treated at our center during the neonatal period.
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