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[Forensic characteristics of the cardio-toxic effect of organophosphorus compounds].
Sud Med Ekspert
October 2021
Academician I.P. Pavlov First Saint Petersburg State Medical University, St. Petersburg, Russia.
Objective - to identify the morphological equivalents of the cardiotoxic action of organophosphate poisoning. It was studied 110 fatal organophosphate poisonings in toxicogenic and somatogenic stages. The study of the heart was a comprehensive in term of clinical, biochemical, histological, micromorphometric, histochemical and histoenzymological approaches.
View Article and Find Full Text PDFThe effect of Hydra peptide morphogen (HPM) on quantitative histochemical and morphometric parameters of the thyroid gland (TG) was studied. The experiments were conducted on 40 outbred albino male mice weighing 20-25 g, which were injected intraperitoneally with HPM at the dose of 100 μg/kg of body weight per day for 5 days. Relative volumes occupied by the epithelium (E), including its follicular (E(f)), interfollicular (E(i)) components, and colloid (C) were determined using stereological method on TG transverse sections.
View Article and Find Full Text PDFHistoenzymological methods were used to study metabolism of smooth muscle cells of intramural myocardial arteries during experimental aortic or pulmonary artery stenosis. Aortic stenosis was accompanied by changes in smooth muscles of the left ventricle manifested by deceleration of tricarboxylic acid cycle, inhibition of oxidation of free fatty acids and their metabolites, flux redistribution in the glycolytic cascade, and inhibition of shuttle systems and biosynthetic processes. Similar metabolic alterations were observed in vessels of the ventricular septum, but they were not revealed in vessels of the right ventricle (except glycolysis stimulation).
View Article and Find Full Text PDFMuscle histopathology in nebulin-related nemaline myopathy: ultrastrastructural findings correlated to disease severity and genotype.
Acta Neuropathol Commun
April 2014
Unité de Morphologie Neuromusculaire, Institut de Myologie, Groupe Hospitalier Universitaire La Pitié-Salpêtrière, Paris, France.
Nemaline myopathy (NM) is a rare congenital myopathy characterised by hypotonia, muscle weakness, and often skeletal muscle deformities with the presence of nemaline bodies (rods) in the muscle biopsy. The nebulin (NEB) gene is the most commonly mutated and is thought to account for approximately 50% of genetically diagnosed cases of NM. We undertook a detailed muscle morphological analysis of 14 NEB-mutated NM patients with different clinical forms to define muscle pathological patterns and correlate them with clinical course and genotype.
View Article and Find Full Text PDFHistoenzymological characteristics of the heart conduction system: comparative study with left or right ventricle afterload.
Bull Exp Biol Med
September 2013
N. I. Pirogov Russian National Research Medical University, the Ministry of Health and Social Development of Russia, Moscow, Russia.
Histoenzymological changes, indicating inhibition of the main metabolic processes, were found in the conduction cardiomyocytes of the left ventricle and ventricular septum in experimental stenosis of the aorta. The histoenzymological changes in the conduction system of both ventricles and ventricular septum were similar in experimental stenosis of the pulmonary artery and indicated primarily activation of glycolysis. The histoenzymological profile of conduction cardiomyocytes differed little in cases when the increase of the pressure load was complicated or not complicated by the development of heart failure, particularly in pulmonary artery stenosis.
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