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New meroterpenoids and C-methylated flavonoid isolated from Baeckea frutescens. | LitMetric

New meroterpenoids and C-methylated flavonoid isolated from Baeckea frutescens.

Chin J Nat Med

State Key Laboratory of Natural Medicines, Department of TCMs Pharmaceuticals, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 210009, China. Electronic address:

Published: May 2020

AI Article Synopsis

Article Abstract

Phytochemical investigation of the aerial parts of Baeckea frutescens resulted in the isolation of three new mono- or sesquiterpene-based meroterpenoids, frutescones S-U (1-3), and one pair of new (±)-5,7-dihydroxy-8-isobutyryl-6-methyldihydroflavonol (4). Their structures and absolute configurations were established by HR-ESI-MS, 1D and 2D NMR, and quantum chemical ECD calculation. Compound 1 exhibited inhibitory effect on NO production in LPS-activated RAW 264.7 macrophages with an IC value being 0.81 μmol·L.

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Source
http://dx.doi.org/10.1016/S1875-5364(20)30044-3DOI Listing

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