Conservative treatment given as interrupted courses is easy and successful for the majority of patients with peptic ulcer disease. For those plagued for years and years by severe chronic complaints the choice will be maintenance treatment or surgery. Maintenance treatment possibly spares the patient for an operation but includes a risk of stenosis claiming the necessity of a drainage operation with risk of sequels. The taking of the pill means a daily remembrance of the disease. Relapse rate is high. The economic problem is not unimportant for the patient. When contra indications are taken seriously into consideration modern ulcer surgery is not dangerous. There are no sequels if the pyloric function can be left intact. The cured patients feel fit and will usually forget the disease. Recurrence rate is lower than that during maintenance therapy but if occurring early they may be difficult to treat. The young patient with severe chronic duodenal ulcer disease should not wait eternally for a parietal cell vagotomy. When the ulcer is located to the pyloric channel prolonged conservative treatment may be advisable. Treatment policy for the gastric ulcer is debatable. No treatment is yet ideal. The advice to the individual patient should be based upon a non-prejudiced evaluation of the advantages and disadvantages of the therapeutic possibilities necessitating that the gastroenterologist and the surgeon have a thorough knowledge of the results of the other speciality.
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http://dx.doi.org/10.3109/00365528809096297 | DOI Listing |
Circ Cardiovasc Interv
January 2025
Hospital Henri Mondor, Cardiologie, Creteil, France (T.T., A.S.T.-M., A. Molho, P.-M.C., P.Z., A.D.P., L.R., A. Mangiameli, E.T., M. Boukantar, R.G.).
J Glob Health
December 2024
Department of Anesthesiology, Critical Care and Pain Medicine, UTHealth, Houston, Texas, USA.
Background: Previous studies have shown that hypertonic saline nasal irrigation and gargling reduced the duration of symptoms in upper respiratory infections caused by coronavirus. This study aims to investigate the effects of two saline regimens on symptoms associated with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2).
Methods: Between 2020 and 2022, individuals aged 18-65 years who tested positive for SARS-CoV-2 infection via polymerase chain reaction (PCR) were randomly assigned to either low- or high-saline regimens for 14 days.
Dev Psychopathol
January 2025
Department of Psychology, University of Wisconsin-Madison, Madison, WI, USA.
Polygenic scores (PGSs) have garnered increasing attention in the clinical sciences due to their robust prediction signals for psychopathology, including externalizing (EXT) behaviors. However, studies leveraging PGSs have rarely accounted for the phenotypic and developmental heterogeneity in EXT outcomes. We used the National Longitudinal Study of Adolescent to Adult Health (analytic = 4,416), spanning ages 13 to 41, to examine associations between EXT PGSs and trajectories of antisocial behaviors (ASB) and substance use behaviors (SUB) identified via growth mixture modeling.
View Article and Find Full Text PDFCureus
December 2024
Family Medicine, Augusta University Medical College of Georgia, Chatsworth, USA.
Hairy cell leukemia (HCL) is a rare, chronic B-cell malignancy with an indolent course that typically responds well to purine nucleoside analogs, such as cladribine. We present the case of a 74-year-old woman with nearly three decades of recurrent HCL, marked by multiple relapses and significant toxicities to various treatments, including purine analogs, BRAF inhibitors, BTK inhibitors, a cytoreductive agent, and the monoclonal antibody rituximab. Despite severe allergic reactions and intolerances to standard therapies, the patient achieved multiple remissions.
View Article and Find Full Text PDFCureus
December 2024
Department of Obstetrics and Gynaecology, Tata Main Hospital, Jamshedpur, IND.
An uncommon and recently identified Müllerian anomaly is the accessory cavitated uterine mass (ACUM). It is distinguished by the presence of a noncommunicating auxiliary cavity inside the uterus, located near and surrounded by uterine smooth muscle, and bordered by functioning endometrium beneath the round ligament's insertion, with a perfectly healthy uterus, ovaries, tubes, and cavity. Given that it is a congenital ailment with a persistent Müllerian duct at the level of the round ligament, primarily resulting from gubernaculum dysfunction, it usually manifests clinically as childhood dysmenorrhea in girls.
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