AI Article Synopsis
- Recent advancements in dual-catalytic strategies for decarboxylative elimination of carboxylic acids are gaining interest.
- Our lab's previous work introduced a photoredox/cobaloxime dual catalytic method to synthesize enamides and enecarbamates from N-acyl amino acids without the need for stoichiometric reagents.
- Ongoing developments have enhanced this transformation's effectiveness and yielded new insights into the reaction mechanism, which could help expand the application of photoredox/cobalt dual-catalytic systems.
Article Abstract
Recently, dual-catalytic strategies towards the decarboxylative elimination of carboxylic acids have gained attention. Our lab previously reported a photoredox/cobaloxime dual catalytic method that allows the synthesis of enamides and enecarbamates directly from N-acyl amino acids and avoids the use of any stoichiometric reagents. Further development, detailed herein, has improved upon this transformation's utility and further experimentation has provided new insights into the reaction mechanism. These new developments and insights are anticipated to aid in the expansion of photoredox/cobalt dual-catalytic systems.
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| http://dx.doi.org/10.1002/chem.202001952 | DOI Listing |
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