A novel method for the analysis of nalbuphine hydrochloride (NAL) is reported based on its enhancement effect on a diperiodatoargentate(III)-rhodamine-B (Ag(III) complex-Rh-B) chemiluminescence (CL) system in an aqueous sulfuric acid medium using flow-injection analysis (FIA). The optimal conditions of the CL reaction were: sulfuric acid, 10 M; Ag(III) complex, 2.0 × 10 M; Rh-B, 2.0 × 10 M; Brij-35, 0.01%; sample loop volume, 300 μL; and flow rate, 3.0 mL/min/stream. The limit of detection (LOD) and limit of quantification (LOQ) were 0.001 and 0.003 mg/L (S/N = 3 and 10); linear calibration range, 5 × 10 - 5.0 mg/L (R = 0.9999) and injection throughput, 150/h. The relative standard deviation (RSD) was from 0.8 - 3.2% over the range studied. The suggested technique was applied for the determination of NAL in pharmaceutical injections, compared with a reported spectrophotometric method, and obtained results were found to be satisfactory. Based on spectrophotometric studies, the most probable mechanism of the CL reaction has been briefly described and drawn schematically.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.2116/analsci.20P126 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
A Comparative Study of Nalbuphine, Clonidine, and Dexmedetomidine as Adjuvants to Ropivacaine in Epidural Anesthesia for Lower Limb Surgery.
Cureus
December 2024
Anesthesiology and Critical Care, Uttar Pradesh University of Medical Sciences, Etawah, IND.
Background: In epidural anaesthesia, the addition of an adjuvant to local anaesthetics enhances the efficacy, thereby providing increased duration and intensity of blockade in lower limb surgeries. The aim was to compare the efficacy, onset, and duration of sensory and motor blockade; haemodynamic changes; and sedative and analgesic effects of nalbuphine, clonidine, and dexmedetomidine as an adjuvant to ropivacaine in epidural anaesthesia.
Methodology: A prospective, randomised, double-blind study among 90 patients after taking consent was divided into three groups (30 patients each; Group D received 15 ml of 0.
Effect of Ropivacaine Combined with Nalbuphine in Erector Spinae Plane Block on Postoperative Analgesia in Lumbar Trauma Surgery: A Single-Center Randomized Controlled Trial.
J Pain Res
January 2025
Department of Anesthesiology, the Second People's Hospital of Wuhu, Wuhu, Anhui, 241000, People's Republic of China.
Background: The erector spinae plane block (ESPB) has been increasingly utilized for postoperative analgesia in thoracic, abdominal, and spinal surgeries. This study evaluated the postoperative analgesic outcomes of ESPB with nalbuphine as a ropivacaine adjuvant for lumbar trauma surgery.
Methods: This randomized double-blind clinical trial included 57 participants who underwent lumbar trauma surgery.
Morphine Versus Nalbuphine as Intra-Articular Medications Following Temporomandibular Joint Arthrocentesis: A Randomized Clinical Trial.
J Craniofac Surg
December 2024
Oral and Maxillofacial Radiology, Ain Shams University. Oral and Maxillofacial Radiology, Badr University in Cairo.
Purpose: This study aimed at comparing the therapeutic effect of nalbuphine in comparison to morphine after Temporomandibular joint (TMJ) arthrocentesis in patients with anterior disc displacement without reduction (ADDwoR).
Materials And Methods: Twenty-four female patients diagnosed with ADDwoR. Patients were treated with TMJ arthrocentesis then randomly divided into parallel groups.
The efficacy and safety of remimazolam in painless colonoscopy: a prospective, randomized clinical trial.
Front Med (Lausanne)
November 2024
Department of Pain Management, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China.
Article Synopsis
- Remimazolam is a new intravenous anesthetic that aims to provide effective sedation for colonoscopy with fewer cardiovascular and respiratory side effects compared to propofol.
- A clinical study involving 225 patients evaluated two doses of remimazolam against propofol, focusing on sedation success rates, safety, and recovery times.
- Results showed high sedation success (100%) for high-dose remimazolam and propofol, but lower (89%) for low-dose remimazolam, plus lower adverse effects in remimazolam groups compared to propofol.
Analgesic effect of lateral femoral cutaneous nerve block to the pericapsular nerve group (PENG) block in primary total hip arthroplasty: a randomized clinical trial.
Minerva Anestesiol
December 2024
Department of Orthopedics and Anesthesiology, Faculty of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil.
Background: Adequate hip joint and surgical incision analgesia represent a challenge in the postoperative period of primary total hip arthroplasty (THA). This study aimed to evaluate whether the combination of the lateral femoral cutaneous nerve block (LFCN block) and the pericapsular nerve group block (PENG block) influences postoperative analgesia and rescue opioids, in primary THA surgeries.
Methods: A trial was proposed with 74 patients for THA surgeries under spinal anesthesia, where 37 received PENG block (GPENG) and the other 37, PENG block and LFCN block (GPENG+LFC).
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!