AI Article Synopsis
- Congenital hyperinsulinism (CHI) is a condition affecting the pancreas, where targeted surgical options may be used for focal forms, while diffuse forms often require more extensive treatment.
- In a study of 19 children showing signs of CHI, F-DOPA PET/CT scans were performed to identify focal abnormalities, with results indicating that 10 children had focal forms, leading to successful surgical interventions for 4 of them.
- The study concluded that F-DOPA PET/CT is an effective method for locating focal CHI, aiding in the planning of surgical treatments.
Article Abstract
Background: Congenital hyperinsulinism (CHI) is a neuroendocrine disease with focal or diffuse abnormalities in pancreas. While drug-resistant diffuse forms require near-total pancreatectomy or prolonged pharmacotherapy, focal CHI may be treated by targeted surgical resection. We evaluated the usefulness of F-DOPA PET/CT to identify the focal pancreatic form.
Subjects And Methods: Nineteen children (11 boys, 8 girls, aged 2-54 months) with clinical signs of neonatal CHI and positive genetic examinations were enrolled in the study. After i.v. administration of F-DOPA, early PET and late PET/CT acquisition covering one-bed length over thoraco-abdominal region were performed. Both acquisitions were done in dynamic mode to allow exclusion of frames with motion artefacts. Standardized uptake values were adjusted to bodyweight (SUV). The finding was considered as focal when the ratio of SUV between the suspicious region and the rest of pancreas was greater than 1.2.
Results: Focal forms were recorded in 10/19 children and 4 of them underwent surgical resection with complete recovery. Focal uptake was significantly higher than the uptake in the normal pancreatic tissue (p=0.0059). Focal and diffuse forms of CHI did not differ significantly in normal pancreatic tissue uptake. We found no advantage in the measurement of SUV ratio compared to SUV ratio (p=0.50).
Conclusion: F-DOPA PET/CT is a useful tool for the localization of focal CHI and planning of surgical treatment.
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| http://dx.doi.org/10.1016/j.remn.2020.02.005 | DOI Listing |
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