By taking advantage of the efficient Förster resonance energy transfer (FRET) between near-infrared (NIR)-responsive lanthanide-doped upconversion nanoparticles (UCNPs) and Fenton reagent ferrocenyl compounds (), a series of -UCNPs was designed by functionalizing NaYF:Yb,Tm nanoparticles with - surface-coordination chemistry. -UCNP-Lipo nanosystems were then constructed by encapsulating -UCNP inside liposomes for efficient delivery. -UCNP can effectively release ·OH a NIR-promoted Fenton-like reaction. and studies of -UCNP-Lipo confirmed the preferential accumulation in a tumor site followed by an enhanced uptake of cancer cells. After cellular internalization, the released -UCNP can effectively promote ·OH generation for tumor growth suppression. Such a -UCNP-Lipo nanosystem exhibits advantages such as easy fabrication, low drug dosage, and no ferrous ion release.
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