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Effects of two commonly used antidepressants amitriptyline and fluoxetine on the pharmacokinetics of abrocitinib in rats.
Chem Biol Interact
July 2024
The First Affiliated Hospital of Wenzhou Medical University, Zhejiang, China. Electronic address:
Abrocitinib is approved to treat moderate-to-severe atopic dermatitis and eliminated mainly through cytochrome P450 (CYP450) enzyme. Two commonly used antidepressants, amitriptyline and fluoxetine, could inhibit the activities of CYP2C19 and CYP3A4. In this study, we developed a new and quick ultra performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS) method for quantitatively analyzing the plasma concentration of abrocitinib, and further investigated the effects of amitriptyline or fluoxetine on the pharmacokinetics of abrocitinib in rats.
View Article and Find Full Text PDFTherapeutic potential of orally applied KB-R7943 in streptozotocin-induced neuropathy in rats.
Heliyon
March 2024
Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, St Petersburg, Russia.
Article Synopsis
- Both peripheral neuropathy and depression associated with diabetes can result from sodium-calcium imbalance, prompting a study on the drug KB-R7943 as a potential treatment in a rat model.
- The pharmacokinetic study showed differences in drug exposure and distribution between diabetic rats and controls, with notable accumulation in the brain and heart, but lower penetration in diabetic rats.
- Chronic treatment with KB-R7943 demonstrated dose-dependent improvement in neuropathic and depression-like symptoms, indicating its potential for treating neurodegenerative effects of diabetes, although further safety studies are needed.
Elucidation of escitalopram oxalate and related antidepressants as putative inhibitors of PTP4A3/PRL-3 protein in hepatocellular carcinoma: A multi-computational investigation.
Comput Biol Chem
June 2024
Department of Biochemistry and Molecular Biology, Pondicherry University, Puducherry 605 014, India. Electronic address:
Hepatocellular carcinoma (HCC) persists to be one of the most devastating and deadliest malignancies globally. Recent research into the molecular signaling networks entailed in many malignancies has given some prominent insights that can be leveraged to create molecular therapeutics for combating HCC. Therefore, in the current communication, an in-silico drug repurposing approach has been employed to target the function of PTP4A3/PRL-3 protein in HCC using antidepressants: Fluoxetine hydrochloride, Citalopram, Amitriptyline, Imipramine, and Escitalopram oxalate as the desired ligands.
View Article and Find Full Text PDFThe Relevance of Integrating CYP2C19 Phenoconversion Effects into Clinical Pharmacogenetics.
Pharmacopsychiatry
March 2024
Department of Psychiatry, Psychosomatics and Psychotherapy, University Hospital Frankfurt, 60528 Frankfurt, Germany.
Introduction: CYP2D6 and CYP2C19 functional status as defined by genotype is modulated by phenoconversion (PC) due to pharmacokinetic interactions. As of today, there is no data on the effect size of PC for CYP2C19 functional status. The primary aim of this study was to investigate the impact of PC on CYP2C19 functional status.
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