AI Article Synopsis
- - During a study of chilblains in young patients, four individuals were found with skin lesions resembling erythema multiforme (EM), with limited known triggers for EM.
- - Out of these patients, one tested positive for SARS-CoV-2, while the other three were negative, and skin biopsies showed atypical features not usually seen in EM.
- - Immunohistochemical analysis revealed signs of SARS-CoV/SARS-CoV-2 in skin cells, suggesting a potential connection between EM-like lesions and COVID-19, although all patients had a good recovery with few symptoms.
Article Abstract
During examination of cases of chilblains in children and adolescents, we identified four patients who also showed skin lesions similar to erythema multiforme (EM). They had no other known triggers for EM. One of them had a positive PCR for SARS-CoV-2, while the other three were negative. Skin biopsies from two patients showed features not typical of EM, such as deep perivascular and perieccrine infiltrate and absence of necrosis of keratinocytes. Immunohistochemistry for SARS-CoV/SARS-CoV-2 spike protein showed granular positivity in endothelial cells and epithelial cells of eccrine glands in both biopsies. All patients had an excellent outcome, and had minimal or no systemic symptoms. The coincidence of EM, a condition commonly related to viruses, and chilblains in the setting of COVID-19, and the positivity for SARS-CoV/SARS-CoV-2 spike protein by immunohistochemistry strongly suggest a link between EM-like lesions and SARS-CoV-2.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7283638 | PMC |
| http://dx.doi.org/10.1111/pde.14246 | DOI Listing |
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