There is a higher incidence of stroke in both the type 2 diabetic and the non-diabetic insulin resistant patient which is accompanied by higher morbidity and mortality. The increase in the frequency of stroke is due to an increase in cerebral infarction, mainly lacunar infarcts, with the incidence of cerebral hemorrhage being less frequent. The major risk factors for stroke in the type 2 diabetic patient are age, hypertension, the number of features of the Metabolic Syndrome, the presence of diabetic nephropathy in both the type 1 and type 2 patient, the presence of peripheral and coronary artery disease and especially the presence of atrial fibrillation. Hyperglycemia is associated with a poor outcome from stroke but is not causative.
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http://dx.doi.org/10.1016/j.diabres.2020.108193 | DOI Listing |
Alzheimers Dement
December 2024
Department of Neurosurgery, Clinical Neuroscience Research Center, Tulane University School of Medicine, New Orleans, LA, USA.
Background: Levels of inflammatory components gradually rise in tissues and blood as we age. This "inflammageing" process is often debilitating and even fatal. Cognitive impairment is one example of inflammageing's incapacitating nature.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Background: Association of type 2 diabetes with cognitive decline and incident dementia in older adults remains inconsistent. In this study, we aim to investigate whether subclinical cerebrovascular disease (sCeVD) would modify this relationship.
Method: A total of 654 participants underwent brain MRI at baseline, from whom 592 individuals with at least one follow-up were selected for longitudinal analysis.
Alzheimers Dement
December 2024
Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Background: Endogenous estrogen history across the life course may be associated with better cognitive maintenance. Few large longitudinal studies have evaluated this prospectively, and results have been inconsistent. We assessed the association of reproductive span, an indicator of endogenous estrogen history, with cognitive change in older women.
View Article and Find Full Text PDFCurr Opin Clin Nutr Metab Care
December 2024
Nutrition Foundation of Italy, Milan, Italy.
Purpose Of Review: This paper reviews the most recent literature from January 2023 to August 2024 on the physiological effects of n-6 polyunsaturated fatty acids (PUFAs), with a focus on linoleic acid (LA).
Recent Findings: Contrary to previous concerns that high LA intake may increase inflammation, most recent evidence supports the benefits of LA for cardiometabolic health. Several large studies report that higher blood LA levels correlate with reduced risks of coronary heart disease, stroke, and type 2 diabetes.
Alzheimers Dement
December 2024
IPSIBAT (CONICET/National University of Mar del Plata), Mar del Plata, Buenos Aires, Argentina.
Background: Neuropsychological language assessment batteries usually include connected speech tasks (e.g. the description of a picture).
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