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| http://dx.doi.org/10.1111/ijlh.13244 | DOI Listing |
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Increased Platelet Adhesiveness in Patients with Venous Thromboembolic Disease.
TH Open
October 2024
Thrombosis and Haemostasis Unit, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.
Association between global platelet function and the risk of venous thromboembolic disease (VTE) has been proposed, though the mechanisms do not involve increased platelet aggregation. However, platelet adhesiveness has not been systematically explored in VTE patients. To evaluate platelet adhesive functions in VTE patients.
View Article and Find Full Text PDFTherapeutic targets for hepatocellular carcinoma identified using proteomics and Mendelian randomization.
J Gastroenterol Hepatol
October 2024
The Second Hospital and Clinical Medical School, Lanzhou University, Lanzhou, China.
Article Synopsis
- Hepatocellular carcinoma (HCC) is a serious cancer with high rates of illness and death, driving research into new treatment targets through gene-protein relationships.
- * In this study, researchers analyzed data from multiple sources to identify 10 proteins associated with HCC risk, highlighting the importance of proteins like TFPI2 and ALDH1A1.
- * The findings suggest that targeting these proteins could lead to new therapies for HCC and contribute to the overall fight against cancer.
Acquired thrombotic thrombocytopenic purpura without detectable anti-ADAMTS13 antibodies: a possible underlying autoimmune mechanism.
Haematologica
September 2024
Département de Médecine interne, CHU Charles Nicolle, F-76000 Rouen, France; Université de Rouen, INSERM U1026 EnVI, F-76000 Rouen.
Article Synopsis
- * This study explores the clinical presentation and outcomes of patients with uTTP, highlighting similarities to immune TTP (iTTP).
- * Key features like young age, brain involvement, and severe low platelet counts, especially in those with a history of autoimmune disease or pregnancy, should raise suspicion for iTTP diagnosis.
Autoantibodies to ADAMTS13 in human immunodeficiency virus-associated thrombotic thrombocytopenic purpura.
Vox Sang
December 2024
Department of Haematology and Cell Biology, Faculty of Health Sciences, University of the Free State, Bloemfontein, South Africa.
Background And Objectives: Thrombotic thrombocytopenic purpura (TTP) is a potentially fatal thrombotic microangiopathic disorder that can result from human immunodeficiency virus (HIV) infection. The pathogenesis involves a deficiency of the von Willebrand factor (vWF) cleaving protease ADAMTS13 (a disintegrin and metalloprotease with thrombospondin motifs member 13) and the presence of anti-ADAMTS13 autoantibodies. However, there is insufficient information regarding the epitope specificity and reactivity of these autoantibodies.
View Article and Find Full Text PDFLegionella Pneumophila Presenting as a Rare Cause of Acute Thrombocytopenia: A Case Report and Review of Literature.
Eur J Case Rep Intern Med
August 2024
Department of Pulmonary Critical Care Medicine, University at Buffalo, Buffalo, USA.
Article Synopsis
- The text discusses Legionella infection, which can cause severe health issues ranging from mild flu-like symptoms to serious conditions like pneumonia and multi-organ failure, and may also be linked to rare blood disorders like immune thrombocytopenic purpura (ITP).
- A case study is presented of a 53-year-old man who showed symptoms of pneumonia and severe low platelet count, which was later diagnosed as Legionella infection after positive urine antigen tests.
- It emphasizes the importance of recognizing Legionella as a potential cause in patients with pneumonia and significant thrombocytopenia, as early detection can improve patient outcomes and prevent severe complications.
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