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Model for early allograft function is predictive of early graft loss in donation after circulatory death liver transplantation. | LitMetric

AI Article Synopsis

  • Donation after circulatory death (DCD) liver transplantation has higher graft loss rates, prompting an investigation into the predictive value of the Model for Early Allograft Function (MEAF) in these cases.
  • The study analyzed data from 187 adult DCD liver transplants, finding that a lower MEAF score correlated with significantly better survival rates due to reduced early graft loss.
  • While high MEAF scores indicated early graft loss, they did not predict long-term outcomes, such as the need for retransplantation due to ischemic complications or overall late graft failure.

Article Abstract

Donation after circulatory death (DCD) liver transplantation is associated with higher rates of graft loss. In this paper, we explored whether the Model for Early Allograft Function (MEAF) predicted outcome in DCD liver transplantation. We performed a retrospective analysis of prospectively collected data from all adult DCD (Maastricht 3) livers transplanted in Cambridge and Edinburgh between 1 January 2011 and 30 June 2017, excluding those undergoing any form of machine perfusion. 187 DCD liver transplants were performed during the study period. DCD liver transplants with a lower MEAF score had a significantly better survival compared to those with a high MEAF score (Mantel-Cox P < .0001); this was largely due to early graft loss. Beyond 28 days post-transplant, there were no significant long-term graft or patient survival differences irrespective of the grade of MEAF (Mantel-Cox P = .64 and P = .43, respectively). The MEAF score correlated with the length of ICU (P = .0011) and hospital stay (P = .0007), but did not predict the requirement for retransplantation for ischemic cholangiopathy (P = .37) or readmission (P = .74). In this study, a high MEAF score predicted early graft loss, but not the subsequent need for re-transplantation or late graft failure as a result of intrahepatic ischemic bile duct pathology.

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Source
http://dx.doi.org/10.1111/ctr.13982DOI Listing

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