AI Article Synopsis
- Erectile dysfunction (ED) is a prevalent issue in men linked to factors like age, chronic illnesses, and mental health conditions.
- Phosphodiesterase type 5 inhibitors (PDE5i) are the first-line treatment, but up to 35% of patients do not respond to this therapy.
- Research is now focusing on noncoding RNAs (ncRNAs), such as microRNAs and long noncoding RNAs, to better understand their role in ED and explore new treatment options.
Article Abstract
Erectile dysfunction (ED) is a common male sexual dysfunction and is closely related to many risk factors such as age, chronic diseases and mental disorder. Phosphodiesterase type 5 inhibitor (PDE5i) is recommended as the first-line medicine in therapy, but up to 35% of patients fail to this treatment. Unfortunately, the pathogenesis of ED is still poorly understood. Hence, it has reached the state that researchers should seek for new candidate biomarkers or therapeutic targets. Recent studies have reported that noncoding RNAs (ncRNAs) such as microRNAs (miRNAs) and long noncoding RNAs (lncRNAs) are involved in the pathogenesis process of ED, even in stem cell therapy. In this review, we aim to summarise the mechanisms and functions of identified ncRNAs that are associated with ED.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1111/and.13596 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!