We describe 9 patients at a medical center in Detroit, Michigan, USA, with severe acute respiratory syndrome coronavirus 2 and Clostridioides difficile. Both infections can manifest as digestive symptoms and merit screening when assessing patients with diarrhea during the coronavirus disease pandemic. These co-infections also highlight the continued importance of antimicrobial stewardship.
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http://dx.doi.org/10.3201/eid2609.202126 | DOI Listing |
Expert Rev Gastroenterol Hepatol
January 2025
Division of Gastroenterology and Hepatology, Department of Internal Medicine, University of California San Diego, San Diego, CA.
Introduction: The gut microbiota has a complex relationship with the human host and is key to maintaining health. Disruption of the healthy diverse gut microbial milieu plays an important role in the pathogenesis of several diseases including infection (CDI), inflammatory bowel disease, irritable bowel syndrome, alcohol-related liver disease and metabolic-dysfunction associated steatotic liver disease (MASLD). Fecal microbiota transplantation (FMT) is highly effective in treating CDI, though its utility in other diseases is still being explored.
View Article and Find Full Text PDFLancet Reg Health Eur
February 2025
Infectious Disease Service, Fondazione Policlinico Universitario Campus Bio-Medico, 00127, Rome, Italy.
Antimicrob Steward Healthc Epidemiol
December 2024
Departments of Medicine and Surgery, Washington University School of Medicine, St. Louis, MO, USA.
Objective: To estimate incidence and healthcare costs and mortality associated with infection (CDI) among adults <65 years old.
Design: Retrospective cohort study.
Patients: First CDI episodes among commercially insured US patients 18-64 years old were identified from a large claims database.
Open Forum Infect Dis
January 2025
Geriatric Research Education and Clinical Center (GRECC), VA Northeast Ohio Healthcare System, Cleveland, Ohio, USA.
Background: Primary care providers (PCPs) may modify their antibiotic prescription practices if aware of their potentially damaging impact.
Methods: We conducted a cluster randomized controlled trial at 12 Veterans Affairs community-based outpatient clinics. PCPs at clinics randomized to the intervention group received quarterly antibiotic use reports with feedback about antibiotics prescribed for acute respiratory infections and adverse event letters alerting about infection or antibiotic-resistant gram-negative bacteria among their patients.
J Infect
January 2025
Centre for Medicines Optimisation Research and Education, University College London Hospitals NHS Foundation Trust, London, UK; Research Department of Practice and Policy, School of Pharmacy, University College London, London, United Kingdom; Centre for Safe Medication Practice and Research, Department of Pharmacology and Pharmacy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong; Laboratory of Data Discovery for Health (D24H), Hong Kong Science Park, Hong Kong.
Objective: To assess the characteristics, risk factors and clinical impact of penicillin and other antibiotic allergies labels in general practice in the UK.
Design: Population-based cohort study.
Setting: Primary care in the UK, 2000-2018.
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