Oleanane-type triterpene saponins from leaves and their cytotoxic activity.

Two new, aramatosides A and B ( and ), together with seven known oleanane-type triterpene saponins (-) were isolated from the leaves of . Their structures were determined by combination of HR-ESI-MS, 1 D and 2 D NMR spectral data as well as comparison with the previous literature. Compounds - exhibited cytotoxic effects towards three human cancer cell lines (HT29, A2058, and A549) with IC values ranging from 2.01 ± 0.17 to 18.8 ± 1.17 µM. Especially, compound (narcissiflorin) showed significant cytotoxic activity against HT29 and A549 cell lines with IC values of 2.02 ± 1.65 and 2.01 ± 0.17 µM, respectively, which are smaller than those of positive control irinotecan hydrochloride (IC values of 10.3 ± 1.32 and 9.89 ± 0.19 µM).