Bone turnover, which is determined by osteoclast-mediated bone resorption and osteoblast-mediated bone formation, represents a highly energy consuming process. The metabolic requirements of osteoblast differentiation and mineralization, both essential for regular bone formation, however, remain incompletely understood. Here we identify the nuclear receptor peroxisome proliferator-activated receptor (PPAR) δ as key regulator of osteoblast metabolism. Induction of PPARδ was essential for the metabolic adaption and increased rate in mitochondrial respiration necessary for the differentiation and mineralization of osteoblasts. Osteoblast-specific deletion of PPARδ in mice, in turn, resulted in an altered energy homeostasis of osteoblasts, impaired mineralization and reduced bone mass. These data show that PPARδ acts as key regulator of osteoblast metabolism and highlight the relevance of cellular metabolic rewiring during osteoblast-mediated bone formation and bone-turnover.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7242479PMC
http://dx.doi.org/10.1038/s41598-020-65305-5DOI Listing

Publication Analysis

Top Keywords

bone formation
12
bone mass
8
osteoblast-mediated bone
8
differentiation mineralization
8
key regulator
8
regulator osteoblast
8
osteoblast metabolism
8
bone
7
pparδ-mediated mitochondrial
4
mitochondrial rewiring
4

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!