AI Article Synopsis
- - Neumentix, a novel antioxidative supplement high in rosmarinic acid, shows promise in reducing stroke severity by addressing oxidative stress during acute stroke conditions.
- - In a study with mice, those treated with Neumentix maintained body weight post-stroke and exhibited reduced brain injury compared to the control group.
- - This research is significant as it is the first to confirm Neumentix's antioxidative effects specifically related to strokes, highlighting its potential therapeutic benefits.
Article Abstract
Background: During an acute stroke, reactive oxygen species are overproduced and the endogenous antioxidative defense systems are disrupted. Therefore, antioxidative therapy can be a promising scheme to reduce the severity of stroke. Neumentix is a novel antioxidative supplement produced from a patented mint line and contains a high content of rosmarinic acid (RA). Although Neumentix has proven diverse efficacy and safety in clinical trials, its effect on strokes is unclear.
Methods: Mice that were treated with Neumentix or vehicle for 14 days underwent transient middle cerebral artery occlusion (tMCAO) for 60 min. Mice were sacrificed 5 days after tMCAO.
Results: Neumentix preserved body weight after tMCAO, showed a high antioxidative effect in serum, and reduced infarction volume compared to the vehicle. The expression of 4-hydroxy-2-nonenal, Nε-(carboxymethyl) lysine, and 8-hydroxy-2'-deoxyguanosine was reduced in Neumentix-treated mice.
Conclusion: The antioxidative effect of Neumentix was confirmed. This is the first report to demonstrate the antioxidative effect of Neumentix on strokes.
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Source |
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| http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2020.104818 | DOI Listing |
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