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KIF20A activated by transcription factor GATA2 promotes cell growth in hepatitis B virus-related hepatocellular carcinoma.
Front Cell Infect Microbiol
December 2024
Department of breast surgery, Shanxi Cancer Hospital, Taiyuan, Shanxi, China.
Background: Elevated evidence suggests that KIF20A plays an important role in hepatocellular carcinoma (HCC) progression. Nevertheless, the underlying mechanism by which KIF20A promotes HCC cell growth are not well understood.
Methods: Using TCGA-LIHC RNAseq and GEO datasets, we assessed the KIF20A expression and patient survival in HCC and hepatitis B virus (HBV)-related HCC.
LncRNA MALAT1 promotes Erastin-induced ferroptosis in the HBV-infected diffuse large B-cell lymphoma.
Cell Death Dis
November 2024
Clinical and Translational Research Center of Shanghai First Maternity and Infant Hospital, Shanghai Key Laboratory of Maternal Fetal Medicine, Shanghai Key Laboratory of Signaling and Disease Research, Frontier Science Center for Stem Cell Research, National Stem Cell Translational Resource Center, School of Life Sciences and Technology, Tongji University, Shanghai, 200092, China.
In a retrospective analysis of clinical data from 587 DLBCL (diffuse large B-cell lymphoma) patients in China, 13.8% of cases were associated with HBV (hepatitis B virus) infection, leading to distinct clinical features and poorer prognosis. Moreover, HBV infection has a more pronounced impact on the survival of the GCB (germinal center B-cell-like) type DLBCL patients compared to the ABC (activated B-cell-like) type.
View Article and Find Full Text PDFInsight into the mechanisms regulating liver cancer stem cells by hepatitis B virus X protein.
Infect Agent Cancer
November 2024
Jiangsu Key Laboratory of Immunity and Metabolism, Department of Pathogenic Biology and Immunology, Xuzhou Medical University, Xuzhou, Jiangsu, China.
Hepatocellular carcinoma (HCC) is a heterogeneous disease with high recurrence and mortality. It is well known that a large proportion of HCCs are caused by hepatitis B virus (HBV) infection. In particular, the HBV X protein (HBX), a multifunctional molecule produced by the virus, plays a leading role in hepatocarcinogenesis.
View Article and Find Full Text PDFIdentification and characterization of host factor VCPIP1 as a multi-functional positive regulator of hepatitis B virus.
J Virol
December 2024
Key Laboratory of Medical Molecular Virology (NHC and MOE and CAMS), Department of Medical Microbiology and Parasitology, Shanghai Institute of Infectious Diseases and Biosecurity, School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai, China.
Article Synopsis
- Chronic hepatitis B virus (HBV) infection is a significant public health issue, with viral cccDNA being crucial for HBV replication and life cycle, particularly influenced by the HBx protein.* -
- The study identified VCPIP1, a deubiquitinating enzyme, as a key host protein that interacts with HBx, stabilizing it and enhancing HBV transcription and replication even in the absence of HBx.* -
- VCPIP1 also positively affects HBV promoter and enhancer activities, indicating its role as a multi-functional regulator in the life cycle of the virus.*
Hidden liver-joint axis: HBV infection causes rheumatoid arthritis via TRAFD1 with imbalance of HBV X protein and trans-ferulic acid.
Virulence
December 2024
Department of Clinical Laboratory, Qilu Hospital of Shandong University, Jinan, China.
Liver metabolites are involved in the progression of rheumatoid arthritis (RA), indicating a connection between the liver and joints. However, the impact and mechanism of Hepatitis B virus (HBV), a hepatotropic virus, on RA are still unclear. We investigated the correlation between HBV and RA using Mendelian randomization analysis.
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