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The extraction of polycyclic aromatic hydrocarbons from water samples with aromatic-dithiocarbamate modified magnetic nanoparticles.
Water Sci Technol
September 2022
School of Environmental Science and Engineering, Yancheng Istitute of technology, Yancheng 224051, China.
Considering the urgent need for the analysis of trace-level pollutants in water samples, the pre-concentration of micropollutants in water samples has been the focus of extensive research. Among current pretreatment methods, the solid phase extraction (SPE) technique has received enormous attention because of its low cost, ease of operation and high efficiency. In this work, a new adsorbent (FeO@Au@DTC NPs) was acquired through modification of FeO nanoparticles (NPs) with gold (Au) and dithiocarbamate (DTC).
View Article and Find Full Text PDFBenzo pyrene-induced DNA adducts and gene expression profiles in target and non-target organs for carcinogenesis in mice.
BMC Genomics
October 2014
Analytical and Environmental Sciences Division, MRC-PHE Centre for Environment & Health, King's College London, Franklin-Wilkins Building, 150 Stamford Street, London, SE1 9NH, UK.
Background: Gene expression changes induced by carcinogens may identify differences in molecular function between target and non-target organs. Target organs for benzo[a]pyrene (BaP) carcinogenicity in mice (lung, spleen and forestomach) and three non-target organs (liver, colon and glandular stomach) were investigated for DNA adducts by 32P-postlabelling, for gene expression changes by cDNA microarray and for miRNA expression changes by miRNA microarray after exposure of animals to BaP.
Results: BaP-DNA adduct formation occurred in all six organs at levels that did not distinguish between target and non-target.
Potential biomarkers for head and neck squamous cell carcinoma.
Laryngoscope
March 2003
Department of Otolaryngology-Head and Neck Surgery, Charles R. Drew University of Medicine and Science, 1731 East 20th Street, Los Angeles, CA 90059, USA.
Objective: The purpose of the study was twofold: 1) to search for potential biomarkers that were overexpressed in cell lines that could represent both a clinical premalignant (immortalized) and a malignant state, and 2) to attempt to correlate metallothionein gene expression with clinical outcome in laryngeal carcinoma.
Study Design: A series of in vitro experiments were used to unearth differentially expressed genes among normal, immortalized and tumorigenic cell lines. Secondarily, a retrospective analysis was undertaken.
[Cloning of differentially expressed cDNA sequences involved in malignant transformation induced by benzo(a)pyrene metabolite dihydroxyepoxy benzo pyrene].
Zhonghua Zhong Liu Za Zhi
May 2002
Chemical Carcinogenesis Institute, Guangzhou Medical College, Guangzhou 510182, China.
Objective: To clone differentially expressed cDNA sequences involved in malignant transformation induced by benzo(a)pyrene metabolite dihydroxyepoxy benzo pyrene (BPDE).
Method: The malignant transformation of human bronchial epithelial cell line 16HBE induced by BPDE in vitro was used as a model for comparing gene expression between the transformed cells and controls. cDNA representational difference analysis (cDNA-RDA) was performed to isolate differentially expressed cDNA fragment in transformed cells.
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