AI Article Synopsis
- Phosphodiesterases (PDEs) are a unique enzyme superfamily that helps break down cyclic nucleotides, playing crucial roles in brain development and neurological diseases.
- Each isoform of PDEs can be targeted in specific brain locations, influencing its function and association with various diseases.
- The PDE4B sub-family, in particular, is linked to key brain functions and shows potential as a therapeutic target for conditions like schizophrenia, neuroinflammation, and cognitive issues.
Article Abstract
Phosphodiesterases (PDEs) are the only superfamily of enzymes that have the ability to break down cyclic nucleotides and, as such, they have a pivotal role in neurological disease and brain development. PDEs have a modular structure that allows targeting of individual isoforms to discrete brain locations and it is often the location of a PDE that shapes its cellular function. Many of the eleven different families of PDEs have been associated with specific diseases. However, we evaluate the evidence, which suggests the activity from a sub-family of the PDE4 family, namely PDE4B, underpins a range of important functions in the brain that positions the PDE4B enzymes as a therapeutic target for a diverse collection of indications, such as, schizophrenia, neuroinflammation, and cognitive function.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7291338 | PMC |
| http://dx.doi.org/10.3390/cells9051254 | DOI Listing |
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