AI Article Synopsis
- COVID-19, caused by the 2019-novel coronavirus, poses significant health risks, particularly for individuals with obesity who have compromised immune systems, increasing their vulnerability to infection and severe outcomes.
- A systematic review of studies found that obesity significantly raises the likelihood of requiring advanced medical care, with one high-quality study showing patients with a BMI over 35 kg/m² had a seven-fold higher chance of needing invasive ventilation.
- The findings underscore that obesity is a crucial independent risk factor for severe COVID-19 outcomes, highlighting the need for targeted treatment and prevention strategies for this at-risk group.
Article Abstract
Background And Aims: COVID-19 is an emerging pandemic due to droplet infection of 2019-novel coronavirus (2019-nCoV). Due to its rapid transmission and high case-fatality rate, recognition of its risk and prognostic factor is important. Obesity has been associated with impaired immune system, increasing the susceptibility for 2019-nCoV infection. We aimed to study the impact of obesity to the prognosis and disease severity of COVID-19.
Methods: A systematic search and handsearching was conducted in four databases: Cochrane, MEDLINE, EMBASE, and PubMed. The identified articles were screened using the chosen eligibility criteria. We obtained three retrospective cohort studies (Wu J et al., Lighter J et al., and Simonnet A et al.) to be critically appraised using Newcastle Ottawa Scale.
Results: The findings of all included studies were consistent in stating the contribution of obesity as a risk factor to increase the requirement for advanced medical care. Study with the highest quality, Simonnet A et al., reported an increase need of invasive mechanical ventilation in COVID-19 patients with body mass index higher than 35 kg/m, OR: 7.36 (1.63-33.14; p = 0.021). This is associated with a higher mortality rate in obese population infected with COVID-19.
Conclusion: Obesity is an independent risk and prognostic factor for the disease severity and the requirement of advanced medical care in COVID-19. This systematic review highlights a particularly vulnerable group - obese, and emphasises on the importance of treatment aggression and disease prevention in this population group.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7217103 | PMC |
| http://dx.doi.org/10.1016/j.dsx.2020.05.020 | DOI Listing |
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