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Light-Triggered Electron Transfer between a Conjugated Polymer and Cytochrome C for Optical Modulation of Redox Signaling. | LitMetric

AI Article Synopsis

  • Protein reduction and oxidation processes play crucial roles in many cellular functions and can be influenced by various biochemical stimuli for therapeutic purposes.
  • This study explores the use of light to activate a thiophene-based semiconducting polymer (P3HT) to interact with the Cytochrome c protein (CytC) outside of cells, demonstrating potential applications in redox signaling modulation.
  • The researchers used advanced microscopy techniques to show that light stimulation can trigger reactions that affect CytC's redox activity, offering high precision in controlling protein responses through photochemical processes.

Article Abstract

Protein reduction/oxidation processes trigger and finely regulate a myriad of physiological and pathological cellular functions. Many biochemical and biophysical stimuli have been recently explored to precisely and effectively modulate intracellular redox signaling, due to the considerable therapeutic potential. Here, we propose a first step toward an approach based on visible light excitation of a thiophene-based semiconducting polymer (P3HT), demonstrating the realization of a hybrid interface with the Cytochrome c protein (CytC), in an extracellular environment. By means of scanning electrochemical microscopy and spectro-electrochemistry measurements, we demonstrate that, upon optical stimulation, a functional interaction between P3HT and CytC is established. Polymer optical excitation locally triggers photoelectrochemical reactions, leading to modulation of CytC redox activity, either through an intermediate step, involving reactive oxygen species formation, or via a direct photoreduction process. Both processes are triggered by light, thus allowing excellent spatiotemporal resolution, paving the way to precise modulation of protein redox signaling.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7240120PMC
http://dx.doi.org/10.1016/j.isci.2020.101091DOI Listing

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