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| http://dx.doi.org/10.1016/j.puhe.2020.05.011 | DOI Listing |
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Inhibition of the Integrated Stress Response Prevents Natural Forgetting and Corrects Accelerated Forgetting Associated with Epilepsy.
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Guangxi Key Laboratory of Brain and Cognitive Neuroscience, Faculty of Basic Medical Sciences, Guilin Medical University, Guilin, 541199, Guangxi, China.
The neural mechanisms underlying the natural and maladaptive forgetting of established memory remain largely unknown. Brain disease states might hijack the physiological forgetting mechanisms, resulting in maladaptive forgetting such as accelerated forgetting that contributes to cognitive decline in various neurologic conditions including epilepsy. Based on the key role of the integrated stress response (ISR) in memory storage and maintenance, we determined whether the ISR underpins natural and accelerated forgetting.
View Article and Find Full Text PDFUnraveling distinct potential of pea (Pisum sativum L.) fractions (legumin, vicilin and albumin) by structural and functional characterization.
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State Key Laboratory of Food Science and Resources, Jiangnan University, Wuxi, Jiangsu 214122, China.
Limited and unclear research exists on the individual capacity of major fractions of pea protein legumin (PL), vicilin (PV) and albumin (PA), which collectively contribute to the structural and functional properties of pea protein. Findings revealed that PV (72.26 ± 2.
View Article and Find Full Text PDFStirring the Pot: Antoine Baumé, Josiah Wedgwood, Pierre-Louis Guinand, and the Development of Optical Glass.
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The development of defect-free flint glass for use in telescopes and navigational instruments was a key technological challenge facing European chemists, natural philosophers, and artisans that emerged in the 1750s. In 1805, Pierre-Louis Guinand, a Swiss artisan, invented a fireclay stirrer used to stir molten flint glass to create a homogenous mixture relatively free of defects. In this paper, I show it was not Guinand, but French chemist Antoine Baumé, who first came up with the idea of using a fireclay stirrer.
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Department of Women's and Children's Health, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand.
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Department of Orthopedic Surgery and Orthopedic Research Institute, West China Hospital, Sichuan University, Chengdu, China.
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