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Immunobiology and treatment of cutaneous T-cell lymphoma.
Expert Rev Clin Immunol
August 2024
Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Introduction: Primary cutaneous T cell lymphomas (CTCL) are a heterogenous group of non-Hodgkin lymphomas derived from skin-homing T cells. These include mycosis fungoides and its leukemic variant Sezary syndrome, as well as the CD30+ lymphoproliferative disorders.
Areas Covered: In this review, we provide a summary of the current literature on CTCL, with a focus on the immunopathogenesis and treatment of mycosis fungoides and Sezary syndrome.
Acute mast cell leukemia without KIT D816V mutation and lack of CD2 and CD25-a case report of rare entity.
J Hematop
March 2023
'Diagnostyka S.A.' Medical Laboratories, Warsaw, Poland.
Article Synopsis
- Systemic mastocytosis (SM) is a rare blood cancer characterized by the abnormal growth of mast cells, which can invade the bone marrow and other organs, leading to serious health issues.
- Mast cell leukemia (MCL), a rare subtype of SM, is aggressive and often difficult to treat, as seen in a case where it was initially misidentified as pancreatic cancer.
- The diagnosis of MCL involved examining bone marrow for atypical mast cells and identifying their markers, leading to insights that the patient's severe symptoms stemmed from organ damage due to mast cell accumulation, ultimately resulting in death despite intensive treatment.
Strategy for Pediatric Patients with Relapsed or Refractory Anaplastic Lymphoma Kinase-Positive Anaplastic Large Cell Lymphoma: A Review.
Cancers (Basel)
December 2023
Department of Pediatrics, School of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, 13-1 Takara-machi, Kanazawa 920-8641, Ishikawa, Japan.
Anaplastic lymphoma kinase (ALK)-positive anaplastic large cell lymphoma (ALCL) is an aggressive T-cell lymphoma characterized by large T-cells with strong CD30 and ALK expression. Although conventional chemotherapy is effective in most patients, approximately 30% experience a relapse or refractory disease and have a poor prognosis. Several risk factors associated with poor prognosis have been identified in pediatric ALK-positive ALCL.
View Article and Find Full Text PDFPrimary cutaneous T-cell lymphoma: a review of the most common entities with focus on recent updates.
Hum Pathol
October 2023
Department of Pathology, University of Michigan, Ann Arbor, MI, 48109, USA; Department of Dermatology, University of Michigan, Ann Arbor, MI, 48109, USA. Electronic address:
Article Synopsis
- Cutaneous T-cell lymphomas are rare and varied skin cancers that require teamwork among dermatologists, pathologists, and hematologists/oncologists for accurate diagnosis.
- The article covers common types like mycosis fungoides, Sézary syndrome, and CD30+ T-cell disorders, emphasizing their clinical and histopathologic traits, as well as the challenges in distinguishing them from reactive conditions.
- It also addresses recent updates in diagnostic classification, prognosis, treatment approaches, and the importance of accurate categorization for effective patient outcomes.
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