AI Article Synopsis

Article Abstract

Introduction: During pregnancy, maternal cortisol levels are increased 3-fold by the third trimester. The enzyme 11β-hydroxysteroid dehydrogenase (11β-HSD, isoforms 1 and 2) regulates the balance between cortisol and cortisone levels. Perfluoroalkyl substances (PFAS) have been reported to inhibit 11β-HSD1 and more potently 11β-HSD2, which could lead to reduced levels of cortisol and more extensively cortisone.

Aim: The aim of this work is to investigate a possible effect of early pregnancy PFAS exposure on late pregnancy activity of 11β-HSD1 and 11β-HSD2 assessed by cortisol and cortisone levels in diurnal urine (dU) and blood samples.

Methods: This study is part of the prospective cohort study, Odense Child Cohort (OCC). A total of 1628 pregnant women had serum (S) concentrations of 5 PFAS (perfluorooctanoic acid [PFOA], perfluorooctane sulfonic acid [PFOS], perfluorohexane sulfonic acid [PFHxS], perfluorononanoic acid [PFNA], and perfluorodecanoic acid (PFDA)) measured in the first trimester (median gestational week, GW 11). dU cortisol and cortisone (n = 344) and S-cortisol (n = 1048) were measured in the third trimester (median GW 27).

Results: In multiple regression analyses, a 2-fold increase in S-PFOS was significantly associated with lower dU-cortisone (β = -9.1%, P < .05) and higher dU-cortisol/dU-cortisone (dU-C/C) (β = 9.3%, P < .05). In crude models, a doubling in PFOS, PFOA, PFHxS, and PFNA concentrations were associated with a significant increase in S-cortisol; however, these associations became insignificant after adjustment.

Conclusion: Early pregnancy maternal S-PFAS were inversely associated with late pregnancy dU-cortisone, indicating reduced activity of 11β-HSD2.

Download full-text PDF

Source
http://dx.doi.org/10.1210/clinem/dgaa292DOI Listing

Publication Analysis

Top Keywords

cortisone levels
12
cortisol cortisone
12
early pregnancy
8
late pregnancy
8
third trimester
8
sulfonic acid
8
trimester median
8
pregnancy
5
levels
5
cortisol
5

Similar Publications

Obesity due to excessive body fat accumulation remains a global problem. Patients with obesity have high cortisol levels, and its dysregulation is caused by increased 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) levels. The effects and mechanism of J2H-1702, an 11β-HSD1 inhibitor, on nonalcoholic steatohepatitis (NASH) were explored.

View Article and Find Full Text PDF

Neonatal Pain Management: Is There An Endocrinal Response?

Endocr Metab Immune Disord Drug Targets

January 2025

Department of Pediatrics, El Menshawy General Hospital, Tanta, Egypt.

Neonates exhibit pain responses characterized by various endocrinal changes, including alterations in cortisone and oxytocin serum levels, as well as physiological and emotional reactions. The administration of neonatal pain management leads to the normalization of endocrine hormones, including cortisone and oxytocin, which are affected by the presence of neonatal pain. Diagnosing neonatal pain is complex; however, effective management is essential.

View Article and Find Full Text PDF

A feasibility study on cortisol and cortisone as biomarkers for psychological stress in wastewater-based epidemiology.

Water Res

December 2024

College of Environmental Science and Engineering, Dalian Maritime University, No. 1 Linghai Road, Dalian, , 116026, China. Electronic address:

Psychological stress has a significant impact on individuals' quality of life and health. Traditionally, psychological stress assessment relies on self-reported tools such as the Perceived Stress Scale (PSS), which are inherently subjective. This study aims to evaluate the feasibility of using wastewater-based epidemiology (WBE) to assess cortisol and cortisone as biomarkers for psychological stress.

View Article and Find Full Text PDF

Associations of gestational anxiety and depression with neonatal hair steroid levels.

Psychoneuroendocrinology

December 2024

R&D department, Division of Mental Health Services, Akershus University Hospital, Lørenskog, Norway; Department of Psychiatry, University of Helsinki, Helsinki, Finland; Institute of Clinical Medicine, University of Oslo, Oslo, Norway.

Objective: To investigate the association prenatal maternal depression and anxiety may have on the levels of neonatal hair steroids (i.e. cortisol, cortisone, and the cortisol/cortisone ratio) at birth.

View Article and Find Full Text PDF

Associations of reproductive hormones and stress-related factors with menopausal symptoms.

Menopause

December 2024

From the Department of Neurobiology and Biophysics, Institute of Biosciences, Life Sciences Center, Vilnius University, Vilnius, Lithuania.

Objective: The main aim was to evaluate the relationships between menopausal symptoms, endogenous hormones, and stress-related factors.

Methods: Participants were recruited through online advertisements at Vilnius University and social networks. Sixty-three White Lithuanian women aged 50.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!