Cell organelle targeting of near-infrared croconaine dye controls photothermal outcome.

Chem Commun (Camb)

Department of Chemistry and Biochemistry, University of Notre Dame, 251 Nieuwland Science Hall, Notre Dame, IN 46556, USA.

Published: June 2020

Near-infrared croconaine-peptide conjugates that target the cell nucleus promote photothermal induced cell death. In contrast, a croconaine-morpholine conjugate that targets the cell lysosomes promotes lysosome permeabilization without measurable cell phototoxicity.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7319869PMC
http://dx.doi.org/10.1039/d0cc02612cDOI Listing

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