AI Article Synopsis
- * Elongation Factor P (EF-P) is crucial for protein synthesis and bacterial virulence, but details about its posttranslational modifications in S. aureus are limited.
- * This study focused on expressing EF-P in S. aureus to investigate its posttranslational modifications, successfully identifying the 5-aminopentanol modification using mass spectrometry.
Article Abstract
Antibiotic-resistant Staphylococcus aureus is becoming a major burden on health care systems in many countries, necessitating the identification of new targets for antibiotic development. Elongation Factor P (EF-P) is a highly conserved elongation protein factor that plays an important role in protein synthesis and bacteria virulence. EF-P undergoes unique posttranslational modifications in a stepwise manner to function correctly, but experimental information on EF-P posttranslational modifications is currently lacking for S. aureus. Here, we expressed EF-P in S. aureus to analyze its posttranslational modifications by mass spectrometry and report experimental proof of 5-aminopentanol modification of S. aureus EF-P.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7327921 | PMC |
| http://dx.doi.org/10.1002/2211-5463.12901 | DOI Listing |
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