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| http://dx.doi.org/10.1097/CM9.0000000000000765 | DOI Listing |
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Pharmacodynamic Effect of mTOR Inhibition-based Immunosuppressive Therapy on T- and B-cell Subsets After Renal Transplantation.
Transplant Direct
July 2024
Pediatric Gastroenterology and Hepatology, Department of Pediatrics and Adolescent Medicine, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen, Germany.
Background: The mammalian target of rapamycin inhibitor (mTORi) therapy after kidney transplantation is solely monitored pharmacokinetically, not necessarily reflecting PI3K-Akt-mTOR pathway blockade efficacy leading to potential under-or overimmunosuppression.
Methods: In this cross-sectional study, phosphoflow cytometry was used to determine the efficacy of mTOR inhibition in peripheral T- and B-lymphocyte subsets by assessing p70S6 kinase (p70S6K) phosphorylation in renal transplant recipients upon treatment with a combination of either mTORi and calcineurin inhibitors (n = 18), or mTORi with mycophenolic acid (n = 9). Nine dialysis patients with end-stage renal disease and 17 healthy age-matched volunteers served as controls.
Changes in Treg and Breg cells in a healthy pediatric population.
Front Immunol
December 2023
Clinical Immunology and Primary Immunodeficiencies Unit, Allergy and Clinical Immunology Department, Hospital Sant Joan de Déu, Barcelona, Spain.
Article Synopsis
- The study highlights the challenges in interpreting diagnostic results for inborn errors of immunity due to the absence of age-specific reference values for Tregs in children and a lack of consensus on Treg immunophenotypes.
- The researchers compared three definitions of Tregs and examined the frequencies and maturation status of both Tregs and Bregs in a sample of 55 healthy pediatric controls.
- Findings showed significant variability in Treg numbers based on the definition used, a positive correlation between the definitions, and a trend of declining Treg and Breg frequencies as children age, with Breg maturation occurring earlier than Tregs.
Elevated circulating CD19CD24CD38 B cells display pro-inflammatory phenotype in idiopathic membranous nephropathy.
Immunol Lett
September 2023
Department of Laboratory Medicine, The Second Clinical College of Guangzhou University of Chinese Medicine, Guangzhou, China; State Key Laboratory of Dampness Syndrome of Chinese Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China. Electronic address:
CD19CD24CD38 regulatory B cells exert immunosuppressive functions by producing IL-10, but their role in idiopathic membranous nephropathy (IMN) remains elusive. Here, we investigated the frequency and functional changes of circulating CD19CD24CD38 B cells and evaluated the correlation of CD19CD24CD38 B cells with clinical features and T helper cell subsets in IMN patients. Compared with healthy controls (HCs), IMN patients showed an increased frequency of CD19CD24CD38 B cells, but a significant reduction in the percentage of CD19CD24CD38 B cells was observed 4 weeks after cyclophosphamide treatment.
View Article and Find Full Text PDFCD19CD24CD38 regulatory B cells deficiency revealed severity and poor prognosis in patients with sepsis.
BMC Immunol
November 2022
Department of Emergency Medicine and Critical Care, Shanghai East Hospital, Nanjing Medical University, Nanjing, 211166, Jiangsu Province, China.
Background: Sepsis still remains a major challenge in intensive care medicine with unacceptably high mortality among patients with septic shock. Due to current limitations of human CD19CD24CD38 Breg cells (Bregs) studies among sepsis, here, we tried to evaluate Bregs in severity and prognostic value in patients with sepsis.
Methods: Peripheral blood from 58 patients with sepsis and 22 healthy controls was analyzed using flow cytometry to evaluate the frequency and number of Bregs.
Regulatory Role of B Cells and Its Subsets in Hepatitis E Virus Infection.
Biomed Res Int
September 2022
Hepatitis Group, ICMR-National Institute of Virology, Pune, 130/1, Sus Road, Pashan, 411021, Pune, Maharashtra, India.
Antibodies as well as memory B cells are the potential correlates of a protective immune response against hepatitis E virus (HEV) infection. Literature on the role of B regulatory cells (Bregs) in acute viral infections is limited. We have evaluated the role of IL-10 expressing Bregs in HEV infection.
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