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Maternal exposure to legacy PFAS compounds PFOA and PFOS is associated with disrupted cytokine homeostasis in neonates: The Upstate KIDS study (2008-2010).
Environ Int
January 2025
Environmental Health Sciences, College of Integrated Health Sciences, University at Albany, Rensselaer, NY, USA; Department of Epidemiology and Biostatistics, College of Integrated Health Sciences, University at Albany, State University of New York, Rensselaer, NY, USA. Electronic address:
There is growing concern that exposure to per/polyfluoroalkyl substances (PFAS), persistent chemicals used widely to make consumer products water- or grease-proof, may alter immune function, leading to reduced vaccine response or greater susceptibility to infections. We investigated associations between two legacy PFAS (PFOA and PFOS) and infant cytokine levels measured in newborn dried bloodspots (NDBS) from a large population-based birth cohort in Upstate New York, to determine whether exposure to legacy PFAS is associated with variability in cytokine profiles in newborns. We performed adjusted mixed effects regressions for each cytokine against PFOS and PFOA followed by exploratory factor analysis (EFA) on specific cytokine subsets selected via the prior regressions.
View Article and Find Full Text PDFBending the curve of biodiversity loss requires a 'satnav' for nature.
Philos Trans R Soc Lond B Biol Sci
January 2025
Biodiversity Futures Lab, Natural History Museum, London SW7 5BD, UK.
Georgina Mace proposed bending the curve of biodiversity loss as a fitting ambition for the Convention on Biological Diversity. The new Global Biodiversity Monitoring Framework (GBMF) may increase the chances of meeting the goals and targets in the Kunming-Montreal Global Biodiversity Framework (KMGBF), which requires bending the curve. To meet the outcome goals of KMGBF, the GBMF should support adaptive policy responses to the state of biodiversity, which in turn requires a 'satnav' for nature.
View Article and Find Full Text PDFTraditional versus intensive blood glucose control: long-term target range duration and cardiovascular disease risk and all-cause mortality - a real-world cohort study.
Front Endocrinol (Lausanne)
December 2024
Department of Cardiology, Kailuan General Hospital, Tangshan, China.
Objective: For a long time, the dispute about whether improved glycemic control can bring significant benefits has remained unresolved. We aimed to investigate the association of time spent in different fasting glucose target ranges with cardiovascular risk and all-cause mortality in a population with type 2 diabetes (T2DM).
Method: A total of 3460 T2DM patients in the Kailuan cohort were included in this study.
Ultrafast adaptive optics for imaging the living human eye.
Nat Commun
November 2024
School of Optometry, Indiana University, Bloomington, IN, USA.
Adaptive optics (AO) is a powerful method for correcting dynamic aberrations in numerous applications. When applied to the eye, it enables cellular-resolution retinal imaging and enhanced visual performance and stimulation. Most ophthalmic AO systems correct dynamic aberrations up to 1-2 Hz, the commonly-known cutoff frequency for correcting ocular aberrations.
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