AI Article Synopsis
- This review highlights the use of surface-enhanced Raman spectroscopy (SERS) in analyzing microRNAs (miRNA) and emphasizes important factors that enhance SERS signals, such as special substrates and nanoprobes.
- It categorizes various nanomaterials used in SERS for miRNA analysis based on their roles in biosensing.
- The article also addresses the current advancements in SERS detection of intracellular miRNA and discusses both the potential and the challenges faced by SERS nanosensors in this field.
Article Abstract
This review focuses on emerging applications of surface-enhanced Raman spectroscopy (SERS) optical nanosensors for miRNA analysis, in which the key enhancement factors of the SERS signal, i.e. SERS-active substrates, SERS nanoprobes and nano-assembly strategy, are emphasized. This article includes many nanomaterials for miRNA analysis by the SERS technique. We summarize these reported nanomaterials mainly according to their function in the miRNA assay biosensor. We also briefly summarize the research progress of these nanomaterials in SERS detection of intracellular miRNA. Finally, we discussed the prospect and limitations of SERS nanosensors for analyzing miRNA.
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| http://dx.doi.org/10.1039/d0tb00280a | DOI Listing |
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