Research on arterial hypertension is being conducted in the Soviet Union under a program organized by the National Cardiology Research Center. Four program directions are included: (a) basic research on the pathophysiologic mechanisms in the development of hypertension, including vascular wall viscosity and elasticity, associated regulatory mechanisms, and molecular and cellular mechanisms of vascular tone; (b) clinical research on the pathophysiology of hypertension and the mechanisms responsible for the course and prognosis of the disease, including biobehavioral and psychological aspects and the effects of sodium kinetics and a sodium-limiting diet; (c) approaches to treatment, both pharmacologic and nonpharmacologic; and (d) population studies of children, adolescents, and adults.
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J Formos Med Assoc
January 2025
Department of Neurology, National Taiwan University Hospital, Taipei, Taiwan. Electronic address:
Controlling hypertension has become an important issue in the elderly population in whom neurological comorbidities are highly prevalent. Most of the large-scale trials focusing on hypertension management in older populations have excluded patients with comorbid neurological disorders. However, this population requires special considerations, as the benefits of antihypertensive agents are mostly uncertain and there is a higher risk of adverse events.
View Article and Find Full Text PDFUrol Oncol
January 2025
Department of Rheumatology, Stanford University Medical Center, CA.
Background: Prostate cancer treatment involves hormonal therapies that may carry cardiovascular risks, particularly for long-term use. Gonadotropin-releasing hormone (GnRH) antagonists, such as degarelix, may offer advantages over agonists, but comprehensive comparative cardiovascular outcomes are not well established. This study aimed to systematically review and analyze the cardiovascular safety profiles of degarelix compared to those of traditional GnRH agonists, providing critical insights for optimizing treatment strategies.
View Article and Find Full Text PDFFree Radic Biol Med
January 2025
Division of Neonatology, University & Polytechnic Hospital La Fe, Avda Fernando Abril Martorell 106, 46026 Valencia, Spain; Neonatal Research Group, Health Research Institute Hospital La Fe (IISLAFE), Avda Fernando Abril Martorell 106, 46026 Valencia, Spain; Spanish Network in Maternal, Neonatal, Child and Developmental Health Research (RICORS SAMID) (RD24/0013/0014), Instituto de Salud Carlos III, Madrid, Spain. Electronic address:
Inhaled nitric oxide (iNO) is a selective pulmonary vasodilator that is used as a treatment for persistent pulmonary hypertension in neonates (PPHN) with hypoxic respiratory failure. The generation of reactive oxygen and nitrogen species might induce oxidative/nitrosative damage to multiple organs. There is an increasing scientific and clinical interest in the determination of specific biomarkers to measure the degree of oxidative/nitrosative stress in non-invasively collected biofluids.
View Article and Find Full Text PDFClin Nutr
January 2025
Department of Food Safety, Centre of Sustainable Diets, Norwegian Institute of Public Health, P.O. Box 222, NO-0213 Oslo, Norway. Electronic address:
Background & Aims: Iodine deficiency is linked to multiple adverse health outcomes, but there is scarce knowledge regarding iodine intake and development of chronic hypertension. We aimed to investigate the prospective association between habitual dietary iodine intake and pharmacologically treated hypertension in mothers up to 10 years after delivery.
Methods: The present study is based on data from an ongoing pregnancy cohort and includes 58,629 women without thyroid dysfunction and hypertension at baseline.
J Clin Neurosci
January 2025
Department of Neurology, Gongli Hospital of Shanghai Pudong New Area, No. 219 Miaopu Road, Pudong New Area, Shanghai 200135, China. Electronic address:
Background: Hypertension is one of the most common diseases in the world, impacting global life expectancy and associated with an increased risk of cognitive impairment.
Objective: This study aimed to develop a nomogram that accurately predicts the risk of cognitive impairment in hypertensive patients using the National Health and Nutrition Examination Study (NHANES).
Methods: A total of 1517 hypertensive patients from NHANES 2011-2014 were included in this study.
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