AI Article Synopsis
- Liposomal drug delivery for cancer therapy often faces challenges due to drugs leaking during circulation, which can reduce effectiveness.
- Researchers created a new method that uses a stiff nanobowl embedded in the liposomal water cavity to enhance the stability of doxorubicin (DOX) and prevent this leakage.
- This approach not only improves drug delivery to tumors but also boosts antitumor effects, making it a simpler and more effective solution compared to other methods that modify liposome surfaces.
Article Abstract
Liposomal drug delivery for cancer therapy can be limited due to drug leakage in circulation. Here, we develop a new method to enhance the stability of actively loaded liposomal doxorubicin (DOX) through embedding a stiff nanobowl in the liposomal water cavity. Nanobowl-supported liposomal DOX (DOX@NbLipo) resists the influence of plasma protein and blood flow shear force to prevent drug leakage. This approach yields improved drug delivery to tumor sites and enhanced antitumor efficacy. Compared to alternative methods of modifying liposome surface and composition for stability, this approach designs a physical support for an all-aqueous nanoliposomal cavity. Nanobowl stabilization of liposomes is a simple and effective method to improve carrier stability and drug delivery.
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| http://dx.doi.org/10.1021/acs.nanolett.0c00495 | DOI Listing |
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