This article is considered to be the first to deal with the problem of outlier-detection in multivariate circular data. The proposed algorithm is an extension of the Local Outlier Factor (LOF) method. Two different circular distances are used; taking into account the close bounded range of circular variables, and testing all possible permutations. The performance of the algorithm is investigated via an extensive simulation study. The performance of the LOF algorithm has a direct relationship with concentration parameter, while it has an inverse relationship with the sample size. For illustrative purposes, the algorithm has been implemented on two medical multivariate circular data, namely, X-ray beam projectors data and eye data. The extension of the LOF algorithm for other types of directional data such as spherical and cylindrical datasets is worth to be investigated.
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http://dx.doi.org/10.1002/sim.8576 | DOI Listing |
J Gastroenterol
January 2025
Department of Gastroenterology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
Background: Hepatitis B virus (HBV) RNA is an important serum biomarker of hepatic covalently closed circular DNA (cccDNA) transcriptional activity; however, its clinical characteristics remain unclear. This study evaluated the clinical utility of HBV RNA levels in patients with chronic hepatitis B (CHB).
Methods: We studied 87 CHB patients with serum HBV DNA levels ≥ 5.
ACS Omega
December 2024
Computational Medicine Lab, Department of IT Convergence Engineering, Kumoh National Institute of Technology, Gumi 39177, Republic of Korea.
This study introduces an innovative computational approach using hybrid machine learning models to predict toxicity across eight critical end points: cardiac toxicity, inhalation toxicity, dermal toxicity, oral toxicity, skin irritation, skin sensitization, eye irritation, and respiratory irritation. Leveraging advanced cheminformatics tools, we extracted relevant features from curated data sets, incorporating a range of descriptors such as Morgan circular fingerprints, MACCS keys, Mordred calculation descriptors, and physicochemical properties. The consensus model was developed by selecting the best-performing classifier-Random Forest (RF), eXtreme Gradient Boosting (XGBoost), or Support Vector Machines (SVM)-for each descriptor, optimizing predictive accuracy and robustness across the end points.
View Article and Find Full Text PDFAbdom Radiol (NY)
December 2024
All India Institute of Medical Sciences, Ansari Nagar East, New Delhi, 110029, India.
Purpose: To assess diagnostic accuracy of perfusion CT (pCT) based biomarkers in differentiating clear-cell renal cell carcinoma (ccRCC) from non-ccRCC.
Materials And Method: This retrospective study comprised 95 patients with RCCs (70 ccRCCs and 25 non-ccRCCs) who had perfusion CT (pCT) before surgery between January 2017 and December 2022. Two readers independently recorded PCT parameters [blood flow (BF), blood volume (BV), mean transit time (MTT), and time to peak (TTP)] by drawing a circular ROI on the tumor.
ChemSusChem
December 2024
Department of Chemistry, NIS Interdepartmental Centre and INSTM Reference Centre, University of Turin, Via G. Quarello 15 A, 10135, Torino, Italy.
In this contribution, we tackle the replacement of the Hg-based catalyst and fossil-derived isocyanate precursors toward the formulation of a more sustainable polyurethane thermosetting resins (PUs), emulating the performance of a fully fossil-based one employed in industrial encapsulation of optoelectronics. A mixed Bi-Zn catalyst and a 71 % bio-based isocyanate are exploited at this aim through multivariate chemometric approaches, namely Design of Experiment (DoE). DoE allows us to investigate the effect of different formulation factors on selected parameters, such as the film flexibility and transparency or the gel time.
View Article and Find Full Text PDFNeural Netw
March 2025
Beijing Institute of Functional Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing 100053, China. Electronic address:
In neuroscience, phase synchronization (PS) is a crucial mechanism that facilitates information processing and transmission between different brain regions. Specifically, global phase synchronization (GPS) characterizes the degree of PS among multivariate neural signals. In recent years, several GPS methods have been proposed.
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