Fluorescent Tb(III)-MOF for Fe(III) Ion Detection and Treatment Effect in Aortic Dissection by Reducing β-receptor Expression and D-Dimer Production.

Iron is a class of essential elements involved in the metabolic process in all living organisms. However, excessive or deficient iron levels from normal ranges can lead to severe diseases. In this study, a fluorescent Tb(III)-based metal-organic framework with the chemical formula of [Tb(cptpy)] (1, Hcptpy = 4'-(4-carboxyphenyl)-2,2':6',2''-terpyridine) has been prepared under the hydrothermal condition successfully and its properties were determined by X-ray single-crystal diffraction, IR spectra, powder X-ray diffraction (PXRD) thermogravimetric analyses (TGA) and elemental analyses. Luminescent and sensing properties of complex 1 were examined closely, and it is shown that the Tb-MOF has the distinct ability to efficiently and selectively detect the Fe ion and acetone. Furthermore, the RT-PCR was employed to determine the effect of compound on the β-receptor and mmp-9 genes expression in cardiomyocytes. And the ELISA assay was used for the measurement of D-Dimer in the serum after compound treatment.