The role of the pituitary in the regeneration of the adrenal cortex was examined. Enucleation of the left adrenal, and removal of the right adrenal were performed in hypophysectomized rats, in sham-operated control rats and in intact control rats. The mitotic activity of adrenal regenerates was evaluated on the 5th day after enucleation. A statistically significant decrease (p less than 0.001) in the mean mitotic activity rate was noted in the hypophysectomized rats, when compared with both control groups. The results obtained indicate a significant stimulating effect of the pituitary on the regeneration of the adrenal cortex in rats.
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