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Feasibility of very low iodine dose aortoiliac CT angiography using dual-source photon-counting detector CT.
Eur J Radiol
January 2025
Department of Diagnostic and Interventional Radiology, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany; Division of Cardiovascular Imaging, Department of Radiology and Radiological Science, Medical University of South Carolina, Charleston, USA. Electronic address:
Purpose: To evaluate the feasibility of aortoiliac CT-Angiography (CTA) using dual-source photon-counting detector (PCD)-CT with minimal iodine dose.
Methods: This IRB-approved, single-center prospective study enrolled patients with indications for aortoiliac CTA from December 2022 to March 2023. All scans were performed using a first-generation dual-source PCD-CT.
Improved Items for Estimating SF-36 Profile and Summary Component Scores: Construction and Validation of an 8-item QOL General (QGEN) Survey.
Med Care
January 2025
John Ware Research Group (JWRG), Watertown, MA.
Background: Comprehensive health-related quality of life (QOL) assessment under severe respondent burden constraints requires improved single-item scales for frequently surveyed domains. This article documents how new single-item-per-domain (SIPD) QOL General (QGEN-8) measures were constructed for domains common to SF-36 and results from the first psychometric tests comparing scores for the new measure in relation to those for the SF-36 profile and summary components.
Research Design: Online NORC surveys of adults, ages 19-93 (mean=52 y) representing the US population in 2020 (N=1648) included QGEN-8 and SF-36 items measuring physical (PF), social (SF), role physical (RP) and role emotional (RE) functioning and feelings of bodily pain (BP), vitality (VT), and mental health (MH).
Effect of Lemborexant on Daytime Functioning in Adults With Insomnia: Patient-Reported Outcomes From a Phase 3 Clinical Trial.
Prim Care Companion CNS Disord
January 2025
Eisai Inc, Nutley, New Jersey.
Insomnia and some insomnia treatments can impact an individual's daytime functioning. Here, we performed post hoc analyses of patient-reported outcomes from a phase 3 clinical trial to assess the impact of lemborexant (LEM), a dual orexin receptor antagonist, on daytime functioning. Adults with insomnia were randomized 1:1:1 to receive placebo, LEM 5 mg (LEM5) or LEM 10 mg (LEM10) for 6 months.
View Article and Find Full Text PDFSemi-supervised learning from small annotated data and large unlabeled data for fine-grained Participants, Intervention, Comparison, and Outcomes entity recognition.
J Am Med Inform Assoc
January 2025
Department of Biomedical Informatics, Columbia University, New York, NY 10032, United States.
Objective: Extracting PICO elements-Participants, Intervention, Comparison, and Outcomes-from clinical trial literature is essential for clinical evidence retrieval, appraisal, and synthesis. Existing approaches do not distinguish the attributes of PICO entities. This study aims to develop a named entity recognition (NER) model to extract PICO entities with fine granularities.
View Article and Find Full Text PDFPrediction of microbial crude protein flow from the rumen of dairy cattle by means of dietary characteristics - a meta-analysis.
Arch Anim Nutr
January 2025
Institute of Animal Science, University of Bonn, Bonn, Germany.
Protein supply to ruminants relies mainly on the flow of microbial crude protein (MCP) from the rumen, which is commonly assumed to primarily depend on energy supply. This study evaluated this assumption with recent data and tested if ruminally fermented organic matter (FOM) was a better predictor of MCP flow than total-tract digestible organic matter (DOM) and if more variables could improve the prediction of MCP flow. A previously published data set was extended by additional studies resulting in a data set of 139 studies including 407 treatment means, typical to Central European rations.
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