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Strategies for hepatitis B booster vaccination among children: an 8-year prospective cohort study. | LitMetric

Strategies for hepatitis B booster vaccination among children: an 8-year prospective cohort study.

Hum Vaccin Immunother

State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University, Hangzhou, China.

Published: November 2020

AI Article Synopsis

  • Ongoing debate exists about the necessity of a booster vaccination for children already receiving the hepatitis B virus (HBV) vaccine during infancy, prompting a study to assess the need for boosters and effective strategies.
  • A cohort study conducted from 2009-2010 involved 4,170 children aged 5-15 in Zhejiang Province, categorized by their pre-booster antibody levels and administered different dosages of HBV vaccinations.
  • The study found that a 10 μg dose with a 0-1-6 month schedule produced the strongest immune response, lasting for at least 8 years; it also suggested that a single booster could effectively support children with lower antibody levels (1 to <10 mIU/mL).

Article Abstract

Debate continues regarding the need for a booster vaccination in children who received a universal infant hepatitis B virus (HBV) vaccination. The aim was to explore the need and the strategies for the booster HBV vaccination. 8-year prospective cohort study was conducted among children aged 5-15 years in 2009-2010 in Zhejiang Province. The participants were divided into groups A (<0.1 mIU/mL), B (0.1 to < 1 mIU/mL) and C (1 to <10 mIU/mL) according to the pre-booster anti-HBs antibody levels. 5 μg (group I), 10 μg (group II), 20 μg hepatitis B vaccines (group III) or 5 μg hepatitis A and B (HAB) vaccines (group IV) with 0-1-6-month schedule were randomly administered to children negative for all markers. Blood samples were collected at baseline HBV marker testing, 1 month after the first dose, 1 month, 1 year, 5 years and 8 years after the third dose. Among 4170 children, 2326 (55.8%) were negative for all HBV markers. Group II showed the highest seropositive rates of 92.8%, 99.7%, 97.6%, 90.3% and 83.4% with GMTs of 4194.5 mIU/ml, 4163.9 mIU/ml, 466.9 mIU/ml, 190.6 mIU/ml, 122.6 mIU/ml from 1 month after dose 1 to 8 years after dose 3, respectively ( < .01). Participants in group C showed seropositive rates of 98.9%, 99.9%, 99.5%, 95.5%, 92.8% after the revaccination with GMTs of 6519.6 mIU/ml, 5267.4 mIU/ml, 547.1 mIU/ml, 249.5 mIU/ml, 155.3 mIU/ml, respectively, higher than group A and B ( < .001), except 1 month after the third dose. The 10 μg of HBV vaccine with a 0-1-6-month booster regimen may elicit robust responses and persist for 8 years or longer. Additionally, 1-dose revaccination maybe suitable for children with 1 to < 10 mIU/ml anti-HBs titers.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7733985PMC
http://dx.doi.org/10.1080/21645515.2020.1738169DOI Listing

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