AI Article Synopsis
- The review highlights advancements over the past decade in synthesizing substituted benzofurans, which serve as important building blocks for natural products and pharmaceuticals.
- It focuses on the development of new methods for forming carbon-carbon (C-C) and carbon-oxygen (C-O) bonds using transition-metal catalysis or metal-free techniques, detailing both intramolecular and intermolecular cyclization processes.
- The document also outlines specific bond formation routes for ring generation and benzannulation, culminating in a summary of the progress made in this area.
Article Abstract
This review describes the progress of the last decade on the synthesis of substituted benzofurans, which are useful scaffolds for the synthesis of numerous natural products and pharmaceuticals. In particular, new intramolecular and intermolecular C-C and/or C-O bond-forming processes, with transition-metal catalysis or metal-free are summarized. (1) Introduction. (2) Ring generation via intramolecular cyclization. (2.1) C7a-O bond formation: (route a). (2.2) O-C2 bond formation: (route b). (2.3) C2-C3 bond formation: (route c). (2.4) C3-C3a bond formation: (route d). (3) Ring generation via intermolecular cyclization. (3.1) C7a-O and C3-C3a bond formation (route a + d). (3.2) O-C2 and C2-C3 bond formation: (route b + c). (3.3) O-C2 and C3-C3a bond formation: (route b + d). (4) Benzannulation. (5) Conclusion.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7288127 | PMC |
| http://dx.doi.org/10.3390/molecules25102327 | DOI Listing |
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