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Investigating pain-related medication use and contribution to polypharmacy in adults with intellectual disabilities: a systematic review.
BMC Med
December 2024
General Practice & Primary Care, School of Health & Wellbeing, University of Glasgow, Glasgow, G12 8TB, UK.
Background: Adults with intellectual disability experience more pain than adults without and, despite a higher number of medications being prescribed, may be less likely to receive medication for pain. We conducted a systematic review of existing literature on medication for pain and painful conditions in adults with intellectual disability to explore if there is any association with polypharmacy, multimorbidity or demographic characteristics.
Methods: This systematic review followed PRISMA guidelines.
The association between falls and fall-risk-increasing drugs among older patients in out-patient clinics: A retrospective cohort, single center study.
Res Social Adm Pharm
February 2025
Faculty of Medicine, Thammasat University, Pathum Thani, 10120, Thailand.
Article Synopsis
- * A study involving 19,705 patients age 65 and older revealed that 33% were prescribed FRIDs, with an overall fall incidence of 1.48%. The risk of falls was notably higher for those on FRIDs, especially among females and patients over 70.
- * The results indicate a clear association between FRIDs and increased fall risks, emphasizing the importance of careful medication management in elderly patients to mitigate these risks.
A Pharmacokinetic Study of the Interaction Between Regorafenib and Paracetamol in Male Rats.
Pharmaceutics
October 2024
Department of Clinical Pharmacy and Biopharmacy, Poznań University of Medical Sciences, Rokietnicka 3, 60-806 Poznań, Poland.
: In clinical practice, the prevalent problem of polypharmacy could result in increased risks of drug-drug interactions. Regorafenib (REG) is commonly co-administered with paracetamol (PA) as a treatment protocol in cancer patients with pain therapy. : This study aimed to demonstrate the effect of paracetamol on the pharmacokinetic parameters of regorafenib and its metabolites following a single administration of both substances in rats.
View Article and Find Full Text PDFAn Evaluation of Drug Prescribing Patterns and Prescription Completeness.
Healthcare (Basel)
November 2024
Department of Pediatrics, College of Medicine, University of Hai'l, Hai'l 55476, Saudi Arabia.
The rational use of medicines, in accordance with the World Health Organization (WHO) guidelines, is crucial for optimizing healthcare outcomes. This cross-sectional study aimed to evaluate drug prescribing patterns and assess prescription completeness based on the WHO core drug use criteria. A comprehensive analysis was conducted at the University Clinic in the Northern region, Kingdom of Saudi Arabia (KSA).
View Article and Find Full Text PDFCushing's Myopathy in Dogs: Prevalence, Clinical Abnormalities, and Response to Treatment.
Animals (Basel)
October 2024
Specialists in Companion Animal Neurology, Naples, FL 34135, USA.
A distinct myotonia is a muscle disorder that may occur secondary to excess corticosteroids (hyperadrenocorticism, HAC, or Cushing's disease) and is associated with electrodiagnostic abnormalities on electromyography (EMG). Clinically these disorders cause muscle stiffness, weakness, atrophy, and/or contractures, which can severely limit the quality of life of those affected. To date, there are very few published data regarding the onset, development, and treatment of hyperadrenocorticism-associated myotonia/pseudomyotonia.
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