A smart contact lens can be used as an excellent interface between the human body and an electronic device for wearable healthcare applications. Despite wide investigations of smart contact lenses for diagnostic applications, there has been no report on electrically controlled drug delivery in combination with real-time biometric analysis. Here, we developed smart contact lenses for both continuous glucose monitoring and treatment of diabetic retinopathy. The smart contact lens device, built on a biocompatible polymer, contains ultrathin, flexible electrical circuits and a microcontroller chip for real-time electrochemical biosensing, on-demand controlled drug delivery, wireless power management, and data communication. In diabetic rabbit models, we could measure tear glucose levels to be validated by the conventional invasive blood glucose tests and trigger drugs to be released from reservoirs for treating diabetic retinopathy. Together, we successfully demonstrated the feasibility of smart contact lenses for noninvasive and continuous diabetic diagnosis and diabetic retinopathy therapy.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7182412 | PMC |
| http://dx.doi.org/10.1126/sciadv.aba3252 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Silver Nanoparticles-Functionalized Textile against SARS-CoV-2: Antiviral Activity of the Capping Oleylamine Molecule.
ACS Appl Mater Interfaces
January 2025
Instituto de Química, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-909, Brazil.
COVID-19 disease, triggered by SARS-CoV-2 virus infection, has led to more than 7.0 million deaths worldwide, with a significant fraction of recovered infected people reporting postviral symptoms. Smart surfaces functionalized with nanoparticles are a powerful tool to inactivate the virus and prevent the further spreading of the disease.
View Article and Find Full Text PDFMimicking osteoid 3D porous dense microfiber silk fibroin embedded poly(vinyl alcohol) scaffold for alveolar ridge preservation.
Regen Biomater
November 2024
Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Prince of Songkla University, Hatyai 90110, Thailand.
Alveolar ridge loss presents difficulties for implant placement and stability. To address this, alveolar ridge preservation (ARP) is required to maintain bone and avoid the need for ridge augmentation using socket grafting. In this study, a scaffold for ARP was created by fabricating a 3D porous dense microfiber silk fibroin (mSF) embedded in poly(vinyl alcohol) (PVA), which mimics the osteoid template.
View Article and Find Full Text PDFEvaluation of therapy support through a standardized nursing consultation for patients undergoing oral tumor therapy in gynecological oncology within the prospective CAMPA initiative.
Eur J Oncol Nurs
December 2024
Dept of Gynecology and Obstetrics and CCC Munich, LMU University Hospital, LMU Munich, Germany; Bavarian Cancer Research Center (BZKF), Munich, Germany. Electronic address:
Purpose: The increase of oral tumor therapies (OTT) poses new challenges in patient care. Within CAMPA (Care improvement for advanced or metastatic breast and ovarian cancer patients treated with PARP-inhibitors), additional nursing support for patients treated with PARP-inhibitors was developed.
Methods: Additional nursing support (1 year) was evaluated in breast and gynecooncological cancer patients at an academic and a non-academic outreach center.
Fast fabrication of stimuli-responsive MXene-based hydrogels for high-performance actuators with simultaneous actuation and self-sensing capability.
J Colloid Interface Sci
January 2025
Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, Nanjing Forestry University, Nanjing 210037 China; College of Chemical Engineering, Jiangsu Key Lab for the Chemistry & Utilization of Agricultural and Forest Biomass, Nanjing Forestry University, Nanjing 210037 China. Electronic address:
Poly(N-isopropylacrylamide) (PNIPAM) composite hydrogels have recently emerged as promising candidates for soft hydrogel actuators. However, developing a facile and fast method to obtain multifunctional PNIPAM hydrogel actuators with simulating biological versatility remains a major challenge. Herein, we developed a fast-redox initiation system to prepare PNIPAM/sodium carboxymethyl cellulose (CMC)/TCT MXene nanocomposite hydrogel with multidirectional actuating behaviors and improved mechanical properties.
View Article and Find Full Text PDFEfficiently enhanced short-chain fatty acids (SCFAs) recovery from food waste condensate: Real-time wettability monitoring with supported liquid membrane contactor.
Water Res
January 2025
Department of Global Smart City, Sungkyunkwan University (SKKU), 2066, Seobu-ro, Jangan-gu, Suwon, Gyeonggi-do 16419, Republic of Korea. Electronic address:
Food waste condensate (FWC) is a valuable source for recovering short-chain fatty acids (SCFAs) through methods such as supported liquid membrane contactors. Containing organic compounds like acetate, propionate, and butyrate, FWC offers a rich substrate for efficient SCFA extraction. Recovering SCFAs from FWC provides notable environmental advantages, including reducing waste and generating high-value products for industries such as bioenergy and chemical production.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!